SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 GLY A 191
ASN A 167
GLY A 209
VAL A 184
LEU A 195
 None
 0.94A 1jg4A-4kc8A:
undetectable		 1jg4A-4kc8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 11 LEU A 214
TYR A 265
GLY A 186
GLY A 191
TYR A 226
 None
 1.10A 1p91A-4kc8A:
undetectable		 1p91A-4kc8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 ASN A  71
ASP A  69
ALA A 113
ILE A  94
ARG A  91
 None
 1.21A 1s14B-4kc8A:
undetectable		 1s14B-4kc8A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		4 / 7 ILE A 389
LYS A 387
LEU A 457
ASP A 267
 None
 0.74A 1uwjA-4kc8A:
undetectable		 1uwjA-4kc8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 TYR A 210
VAL A 142
TYR A 160
SER A 144
GLY A 190
 None
 1.19A 2dcfA-4kc8A:
undetectable		 2dcfA-4kc8A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		4 / 6 ARG A 337
GLY A 336
PHE A 304
THR A 301
 None
 1.30A 2m2oB-4kc8A:
undetectable		 2m2oB-4kc8A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 GLY A 324
LEU A 440
VAL A 438
TYR A 421
ASP A 232
 None
 1.45A 2vqyA-4kc8A:
undetectable		 2vqyA-4kc8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 440
THR A 455
GLU A 366
HIS A 346
PHE A 349
 None
 1.07A 2zj0A-4kc8A:
undetectable		 2zj0A-4kc8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 245
HIS A 331
GLU A 223
ASP A 170
GLY A  46
 TRS  A 501 (-4.7A)
None
TRS  A 501 (-2.9A)
TRS  A 501 ( 2.5A)
None
 1.46A 3ce6C-4kc8A:
undetectable		 3ce6C-4kc8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 VAL A 411
PHE A 382
THR A 432
VAL A 433
VAL A 464
 None
 1.17A 3czvA-4kc8A:
undetectable
3czvB-4kc8A:
undetectable		 3czvA-4kc8A:
18.82
3czvB-4kc8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 8 GLY A 292
PHE A 294
ILE A 328
PHE A 361
PHE A 307
 None
 1.34A 3ko0O-4kc8A:
undetectable
3ko0Q-4kc8A:
undetectable		 3ko0O-4kc8A:
13.27
3ko0Q-4kc8A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 10 ILE A 328
PHE A 361
PHE A 307
GLY A 292
PHE A 294
 None
 1.48A 3ko0R-4kc8A:
undetectable
3ko0T-4kc8A:
undetectable		 3ko0R-4kc8A:
13.27
3ko0T-4kc8A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		4 / 8 LEU A 181
TYR A 175
TYR A 110
TYR A 138
 None
 1.22A 3po7A-4kc8A:
undetectable		 3po7A-4kc8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		4 / 6 TYR A 251
GLY A 313
HIS A  31
THR A 332
 None
None
TRS  A 501 ( 4.7A)
None
 0.98A 3tj7A-4kc8A:
undetectable
3tj7B-4kc8A:
undetectable		 3tj7A-4kc8A:
18.05
3tj7B-4kc8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		4 / 6 TYR A 251
GLY A 313
HIS A  31
THR A 332
 None
None
TRS  A 501 ( 4.7A)
None
 0.98A 3tj7C-4kc8A:
undetectable
3tj7D-4kc8A:
undetectable		 3tj7C-4kc8A:
18.05
3tj7D-4kc8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		3 / 3 SER A 144
GLY A 145
GLN A 146
 None
 0.34A 3v4tH-4kc8A:
undetectable		 3v4tH-4kc8A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 440
THR A 455
GLU A 366
HIS A 346
PHE A 349
 None
 1.20A 4lvcC-4kc8A:
undetectable		 4lvcC-4kc8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 PHE A 307
TYR A 247
GLU A 388
ASP A 391
GLY A 292
 None
 1.40A 4qb9E-4kc8A:
undetectable		 4qb9E-4kc8A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 ASN A  71
ASP A  69
ALA A 113
ILE A  94
ARG A  91
 None
 1.19A 4uroC-4kc8A:
undetectable		 4uroC-4kc8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 440
THR A 455
GLU A 366
HIS A 346
PHE A 349
 None
 1.23A 5axaA-4kc8A:
undetectable		 5axaA-4kc8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 440
THR A 455
GLU A 366
HIS A 346
PHE A 349
 None
 1.22A 5axaC-4kc8A:
undetectable		 5axaC-4kc8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 440
THR A 455
GLU A 366
HIS A 346
PHE A 349
 None
 1.22A 5m66B-4kc8A:
undetectable		 5m66B-4kc8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 11 ASN A 315
LEU A 348
GLY A 364
PRO A 312
LEU A 290
 None
 1.29A 6euqA-4kc8A:
undetectable		 6euqA-4kc8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 440
THR A 455
GLU A 366
HIS A 346
PHE A 349
 None
 1.21A 6gbnA-4kc8A:
undetectable		 6gbnA-4kc8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 440
THR A 455
GLU A 366
HIS A 346
PHE A 349
 None
 1.22A 6gbnC-4kc8A:
undetectable		 6gbnC-4kc8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_1
(-)		 4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43
(Thermotoga
petrophila) 		5 / 12 LEU A 440
THR A 455
GLU A 366
HIS A 346
PHE A 349
 None
 1.21A 6gbnD-4kc8A:
undetectable		 6gbnD-4kc8A:
22.69