SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 5 PHE A 268
TYR A 293
LEU A 283
VAL A 264
 None
 1.45A 1dz6A-4kcaA:
undetectable		 1dz6A-4kcaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 9 ASN A 628
PHE A 555
VAL A 451
GLY A 450
LEU A 625
 None
None
None
None
IOD  A 708 ( 4.7A)
 1.15A 1e7aB-4kcaA:
undetectable		 1e7aB-4kcaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 9 ASN A 628
PHE A 555
VAL A 451
GLY A 450
LEU A 625
 None
None
None
None
IOD  A 708 ( 4.7A)
 1.10A 1e7bA-4kcaA:
undetectable		 1e7bA-4kcaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 LEU A 396
HIS A 491
THR A 392
ASP A 308
GLY A 142
 GOL  A 734 (-4.6A)
None
None
GOL  A 734 (-2.6A)
None
 1.25A 1v8bA-4kcaA:
2.0		 1v8bA-4kcaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 LEU A 396
HIS A 491
THR A 392
ASP A 308
GLY A 142
 GOL  A 734 (-4.6A)
None
None
GOL  A 734 (-2.6A)
None
 1.23A 1v8bB-4kcaA:
undetectable		 1v8bB-4kcaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 LEU A 396
HIS A 491
THR A 392
ASP A 308
GLY A 142
 GOL  A 734 (-4.6A)
None
None
GOL  A 734 (-2.6A)
None
 1.26A 1v8bD-4kcaA:
undetectable		 1v8bD-4kcaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 11 SER A 211
GLY A 209
SER A 208
ASN A 239
ASP A 213
 None
None
None
IOD  A 725 (-4.1A)
None
 0.98A 2c2bE-4kcaA:
undetectable
2c2bF-4kcaA:
undetectable		 2c2bE-4kcaA:
20.45
2c2bF-4kcaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VFT_A_SORA1419_0
(XYLITOL OXIDASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 VAL A 517
HIS A 506
THR A 623
HIS A 553
THR A 631
 None
 1.44A 2vftA-4kcaA:
0.0		 2vftA-4kcaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VFU_A_MTLA1419_0
(XYLITOL OXIDASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 VAL A 517
HIS A 506
THR A 623
HIS A 553
THR A 631
 None
 1.46A 2vfuA-4kcaA:
0.0		 2vfuA-4kcaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 11 CYH A 231
TYR A 233
VAL A 263
VAL A 185
TYR A 344
 None
 1.32A 2w4xA-4kcaA:
undetectable		 2w4xA-4kcaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 6 SER A 135
TYR A 139
VAL A 130
TRP A 230
 None
 1.39A 2x45A-4kcaA:
3.0		 2x45A-4kcaA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 GLU A 499
ARG A 493
PHE A 441
GLY A 399
HIS A 559
 IOD  A 711 ( 4.0A)
IOD  A 711 ( 4.7A)
None
None
None
 1.26A 2xffA-4kcaA:
undetectable		 2xffA-4kcaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 7 PHE A 102
LEU A  80
LEU A  53
LEU A  24
 None
 0.81A 3bgdB-4kcaA:
undetectable		 3bgdB-4kcaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		3 / 3 GLY A 109
ASP A 617
SER A 616
 None
 0.70A 3brfA-4kcaA:
undetectable		 3brfA-4kcaA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		3 / 3 TYR A 233
TYR A 313
GLY A 340
 None
 0.72A 3eteB-4kcaA:
undetectable
3eteD-4kcaA:
undetectable
3eteF-4kcaA:
undetectable		 3eteB-4kcaA:
21.84
3eteD-4kcaA:
21.84
3eteF-4kcaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 LEU A 396
HIS A 491
THR A 392
ASP A 308
GLY A 142
 GOL  A 734 (-4.6A)
None
None
GOL  A 734 (-2.6A)
None
 1.28A 3g1uD-4kcaA:
undetectable		 3g1uD-4kcaA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 GLY A 328
SER A 327
PHE A 363
ASP A 360
ILE A 357
 None
 1.08A 3iv6B-4kcaA:
undetectable		 3iv6B-4kcaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		3 / 3 LYS A 225
ILE A 380
PHE A 388
 None
 0.76A 3j7zS-4kcaA:
undetectable
3j7za-4kcaA:
undetectable		 3j7zS-4kcaA:
9.55
3j7za-4kcaA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 8 LYS A  57
ASP A  26
LEU A  99
LEU A  78
 None
 0.97A 3lm8A-4kcaA:
undetectable
3lm8C-4kcaA:
undetectable		 3lm8A-4kcaA:
16.28
3lm8C-4kcaA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 10 ASN A  83
ALA A  22
LEU A 103
ASN A 106
LEU A 107
 None
IOD  A 722 ( 4.5A)
None
None
IOD  A 722 ( 4.8A)
 1.14A 3o02A-4kcaA:
undetectable
3o02B-4kcaA:
undetectable		 3o02A-4kcaA:
18.76
3o02B-4kcaA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 ASP A 308
SER A 235
ILE A 236
TRP A 217
ASN A 215
 GOL  A 734 (-2.6A)
None
None
GOL  A 734 (-3.7A)
None
 1.48A 3rzeA-4kcaA:
undetectable		 3rzeA-4kcaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		3 / 3 TYR A 405
HIS A 559
ARG A 560
 None
None
IOD  A 706 (-4.6A)
 1.19A 4e7bC-4kcaA:
undetectable		 4e7bC-4kcaA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 7 GLY A 267
GLY A 266
ASN A 305
GLU A 273
 None
 0.91A 4fgkB-4kcaA:
undetectable		 4fgkB-4kcaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 8 HIS A   6
ASP A  26
ASP A  61
ILE A  60
 None
 0.82A 4k0bA-4kcaA:
undetectable		 4k0bA-4kcaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 8 HIS A   6
ASP A  26
ASP A  61
ILE A  60
 None
 0.87A 4l7iA-4kcaA:
undetectable		 4l7iA-4kcaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 7 LEU A 247
THR A 249
THR A 322
MET A 332
 None
IOD  A 730 (-4.3A)
None
None
 0.94A 4mbsA-4kcaA:
undetectable		 4mbsA-4kcaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 11 LEU A  78
LEU A  24
LEU A  99
GLU A 101
LEU A 103
 None
 1.07A 4wg0J-4kcaA:
undetectable
4wg0K-4kcaA:
undetectable
4wg0L-4kcaA:
undetectable		 4wg0J-4kcaA:
2.10
4wg0K-4kcaA:
2.10
4wg0L-4kcaA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 8 GLY A 442
ALA A 398
GLY A 409
PHE A 441
 None
 0.80A 5albL-4kcaA:
undetectable		 5albL-4kcaA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 GLN A 537
ILE A 607
VAL A 608
GLY A 605
PHE A 509
 None
 1.16A 5ergB-4kcaA:
undetectable		 5ergB-4kcaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		3 / 3 SER A 436
TYR A 437
TYR A 371
 IOD  A 723 ( 4.2A)
None
None
 0.54A 5lakA-4kcaA:
0.7
5lakI-4kcaA:
undetectable		 5lakA-4kcaA:
18.94
5lakI-4kcaA:
0.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		3 / 3 SER A 436
TYR A 437
TYR A 371
 IOD  A 723 ( 4.2A)
None
None
 0.62A 5lakC-4kcaA:
undetectable
5lakJ-4kcaA:
undetectable		 5lakC-4kcaA:
18.94
5lakJ-4kcaA:
0.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 LEU A 396
GLU A 376
THR A 392
ASP A 308
GLY A 142
 GOL  A 734 (-4.6A)
GOL  A 734 ( 3.7A)
None
GOL  A 734 (-2.6A)
None
 1.16A 5m5kB-4kcaA:
undetectable		 5m5kB-4kcaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 LEU A 396
HIS A 491
THR A 392
ASP A 308
GLY A 142
 GOL  A 734 (-4.6A)
None
None
GOL  A 734 (-2.6A)
None
 1.22A 5m5kB-4kcaA:
undetectable		 5m5kB-4kcaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 LEU A 396
HIS A 491
THR A 392
ASP A 308
GLY A 142
 GOL  A 734 (-4.6A)
None
None
GOL  A 734 (-2.6A)
None
 1.21A 5m66A-4kcaA:
undetectable		 5m66A-4kcaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		5 / 12 LEU A 396
HIS A 491
THR A 392
ASP A 308
GLY A 142
 GOL  A 734 (-4.6A)
None
None
GOL  A 734 (-2.6A)
None
 1.26A 5utuF-4kcaA:
undetectable		 5utuF-4kcaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		3 / 3 TYR A 387
ASP A 421
ASP A 314
 None
 0.76A 5x6yA-4kcaA:
undetectable		 5x6yA-4kcaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 8 TYR A 379
GLY A 474
ASP A 308
PRO A 219
 None
None
GOL  A 734 (-2.6A)
None
 0.83A 6ag0A-4kcaA:
undetectable		 6ag0A-4kcaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4kca ENDO-1,5-ALPHA-L-ARA
BINANASE
(Bos
taurus) 		4 / 7 GLY A 408
HIS A 501
GLU A 500
GLY A 498
 None
None
None
IOD  A 715 (-4.0A)
 0.91A 6n7fA-4kcaA:
undetectable		 6n7fA-4kcaA:
8.35