SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kcb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE
(uncultured
bacterium) 		4 / 6 ARG A 279
GLY A 342
ASP A 339
TYR A 246
 None
 1.04A 1kf6M-4kcbA:
undetectable
1kf6N-4kcbA:
undetectable		 1kf6M-4kcbA:
20.35
1kf6N-4kcbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE
(uncultured
bacterium) 		4 / 6 GLY A 176
GLN A 183
VAL A 147
ALA A 158
 None
 0.99A 1p6kA-4kcbA:
undetectable		 1p6kA-4kcbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE
(uncultured
bacterium) 		5 / 10 PHE A 191
TYR A 110
LEU A 163
GLY A 169
THR A 127
 None
 1.42A 1rmtA-4kcbA:
undetectable		 1rmtA-4kcbA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE
(uncultured
bacterium) 		4 / 5 ALA A 122
TYR A 111
ILE A 123
ASP A 142
 None
 1.25A 1upfA-4kcbA:
undetectable		 1upfA-4kcbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE
(uncultured
bacterium) 		4 / 5 ALA A 122
TYR A 111
ILE A 123
ASP A 142
 None
 1.11A 1upfC-4kcbA:
undetectable		 1upfC-4kcbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE
(uncultured
bacterium) 		4 / 6 GLU A 141
LYS A 139
PRO A  78
GLU A  79
 None
 1.23A 4a7tF-4kcbA:
undetectable		 4a7tF-4kcbA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE
(uncultured
bacterium) 		3 / 3 TYR A 110
MET A 109
ILE A  52
 None
 0.91A 4c8bB-4kcbA:
undetectable		 4c8bB-4kcbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE
(uncultured
bacterium) 		5 / 12 GLY A 287
THR A 200
ALA A 265
VAL A 249
ASP A 283
 None
 1.44A 4df3B-4kcbA:
undetectable		 4df3B-4kcbA:
21.40