SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kcd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		3 / 3 ASP A 214
LYS A 217
ARG A 172
 None
 1.18A 1ra8A-4kcdA:
2.0		 1ra8A-4kcdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		3 / 3 GLU A 155
THR A 154
LEU A 164
 None
 0.70A 1v8bC-4kcdA:
undetectable		 1v8bC-4kcdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 6 GLY A 146
ILE A 147
ILE A 159
ASP A 224
 None
 0.94A 3a7eA-4kcdA:
undetectable		 3a7eA-4kcdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		5 / 10 ILE A 126
PRO A 139
SER A 142
SER A 144
GLY A 251
 None
 1.29A 3ik6B-4kcdA:
29.7
3ik6E-4kcdA:
29.7		 3ik6B-4kcdA:
29.70
3ik6E-4kcdA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 8 ILE A 126
PRO A 139
SER A 142
GLY A 251
 None
 0.47A 3lslA-4kcdA:
29.7
3lslD-4kcdA:
29.7		 3lslA-4kcdA:
28.81
3lslD-4kcdA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 8 ILE A 126
PRO A 139
SER A 142
GLY A 251
 None
 0.53A 3lslA-4kcdA:
29.7
3lslD-4kcdA:
29.7		 3lslA-4kcdA:
28.81
3lslD-4kcdA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 8 GLY A 110
LEU A 112
LEU A 113
ILE A 134
 None
 0.86A 3nbqB-4kcdA:
undetectable		 3nbqB-4kcdA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		5 / 12 ASP A 224
VAL A 149
ILE A 159
ALA A 181
TYR A 184
 None
 1.03A 3ohtA-4kcdA:
undetectable
3ohtB-4kcdA:
undetectable		 3ohtA-4kcdA:
20.94
3ohtB-4kcdA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		3 / 3 TYR A 252
ASP A 229
ASP A 224
 None
GOL  A 301 (-3.1A)
None
 0.80A 3r24A-4kcdA:
undetectable		 3r24A-4kcdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		5 / 11 ILE A 266
GLY A 255
ALA A 120
THR A 122
VAL A  18
 None
 1.21A 3rukD-4kcdA:
undetectable		 3rukD-4kcdA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 5 ILE A 126
PRO A 139
SER A 123
GLY A 253
 None
 1.11A 3tkdB-4kcdA:
29.7		 3tkdB-4kcdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 5 ILE A 126
PRO A 139
SER A 144
GLY A 251
 None
 1.02A 3tkdB-4kcdA:
29.7		 3tkdB-4kcdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 5 ILE A 126
PRO A 139
SER A 123
GLY A 253
 None
 1.12A 3tkdA-4kcdA:
29.6		 3tkdA-4kcdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 5 ILE A 126
PRO A 139
SER A 144
GLY A 251
 None
 1.06A 3tkdA-4kcdA:
29.6		 3tkdA-4kcdA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 8 SER A 125
ARG A 130
GLU A  14
ASP A 224
 None
 1.10A 4d33A-4kcdA:
undetectable		 4d33A-4kcdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 7 SER A 125
ARG A 130
GLU A  14
ASP A 224
 None
 1.11A 4d33B-4kcdA:
undetectable		 4d33B-4kcdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 7 SER A 125
ARG A 130
GLU A  14
ASP A 224
 None
 1.06A 4d39B-4kcdA:
undetectable		 4d39B-4kcdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 7 PHE A 124
GLY A  98
ILE A 134
PHE A 136
 None
 0.85A 4ejjA-4kcdA:
undetectable		 4ejjA-4kcdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 5 PRO A 205
LEU A 108
TYR A 252
PHE A 141
 None
None
None
GOL  A 301 (-4.0A)
 1.34A 5igjA-4kcdA:
undetectable		 5igjA-4kcdA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 6 TYR A  97
VAL A  10
VAL A 121
THR A 122
 None
 1.26A 6f32B-4kcdA:
undetectable		 6f32B-4kcdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 6 LEU A 240
ASP A 235
ASP A 237
GLN A 209
 None
 1.36A 6g31J-4kcdA:
undetectable		 6g31J-4kcdA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A
(Rattus
norvegicus) 		4 / 8 HIS A 160
GLY A 158
LEU A 145
GLY A 146
 None
 0.69A 6mdqA-4kcdA:
undetectable		 6mdqA-4kcdA:
13.36