SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 SER C 130
VAL C 136
SER C 135
ASP C 133
 None
 1.23A 1hwiB-4kd5C:
undetectable		 1hwiB-4kd5C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 SER C 130
VAL C 136
SER C 135
ASP C 133
 None
 1.19A 1hwkA-4kd5C:
undetectable		 1hwkA-4kd5C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 SER C 130
VAL C 136
SER C 135
ASP C 133
 None
 1.21A 1hwkC-4kd5C:
undetectable		 1hwkC-4kd5C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 SER C 130
VAL C 136
SER C 135
ASP C 133
 None
 1.19A 1hwkD-4kd5C:
undetectable		 1hwkD-4kd5C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 11 GLY C 197
VAL C 147
ILE C 150
GLY C 202
ILE C 129
 None
 0.92A 1n49B-4kd5C:
undetectable		 1n49B-4kd5C:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 11 GLY C 197
VAL C 147
ILE C 150
GLY C 202
ILE C 129
 None
 0.92A 1n49C-4kd5C:
undetectable		 1n49C-4kd5C:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		3 / 3 ASP C 120
GLU C 223
TYR C 205
 None
 0.80A 1wsvA-4kd5C:
undetectable		 1wsvA-4kd5C:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 6 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 1.01A 3abkP-4kd5C:
undetectable
3abkW-4kd5C:
undetectable		 3abkP-4kd5C:
19.08
3abkW-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 7 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 1.02A 3asnP-4kd5C:
undetectable
3asnW-4kd5C:
undetectable		 3asnP-4kd5C:
19.08
3asnW-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 10 THR C 225
PHE C 203
GLU C 166
LEU C 171
LEU C 173
 None
 1.19A 3kvrA-4kd5C:
undetectable		 3kvrA-4kd5C:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 10 THR C 225
PHE C 203
GLU C 166
LEU C 171
LEU C 173
 None
 1.20A 3kvrB-4kd5C:
undetectable		 3kvrB-4kd5C:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		3 / 3 PHE C  96
TYR C 231
LEU C  45
 None
 0.69A 3sueB-4kd5C:
undetectable		 3sueB-4kd5C:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 6 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 1.00A 3wg7C-4kd5C:
undetectable
3wg7J-4kd5C:
undetectable		 3wg7C-4kd5C:
19.08
3wg7J-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 9 LEU C 126
LEU C 191
SER C 207
THR C 209
ILE C 129
 None
 1.30A 4ubsA-4kd5C:
undetectable		 4ubsA-4kd5C:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 5 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 0.94A 5x19C-4kd5C:
undetectable
5x19J-4kd5C:
undetectable		 5x19C-4kd5C:
19.08
5x19J-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 7 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 0.99A 5x1fP-4kd5C:
undetectable
5x1fW-4kd5C:
undetectable		 5x1fP-4kd5C:
19.08
5x1fW-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 7 ILE C 215
GLN C 195
VAL C 194
ALA C 151
 None
 0.78A 6cduC-4kd5C:
undetectable
6cduD-4kd5C:
undetectable		 6cduC-4kd5C:
21.61
6cduD-4kd5C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 7 ALA C 151
ILE C 215
GLN C 195
VAL C 194
 None
 0.82A 6cduF-4kd5C:
undetectable
6cduJ-4kd5C:
undetectable		 6cduF-4kd5C:
21.61
6cduJ-4kd5C:
21.61