SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kd6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4kd6 ENOYL-COA
HYDRATASE/ISOMERASE
(Paraburkholderia
graminis) 		4 / 8 GLY A  64
SER A  62
TRP A  81
TYR A  89
 None
 1.09A 1maaD-4kd6A:
undetectable		 1maaD-4kd6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4kd6 ENOYL-COA
HYDRATASE/ISOMERASE
(Paraburkholderia
graminis) 		4 / 5 GLN A 113
PHE A 220
TRP A 145
GLY A 227
 None
 1.08A 2qmzA-4kd6A:
undetectable
2qmzB-4kd6A:
undetectable		 2qmzA-4kd6A:
23.73
2qmzB-4kd6A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4kd6 ENOYL-COA
HYDRATASE/ISOMERASE
(Paraburkholderia
graminis) 		4 / 8 MET A 129
PHE A 112
GLY A 109
GLY A 118
 None
 0.70A 2y6rB-4kd6A:
undetectable		 2y6rB-4kd6A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4kd6 ENOYL-COA
HYDRATASE/ISOMERASE
(Paraburkholderia
graminis) 		5 / 12 LEU A 176
LEU A  92
LEU A  99
PHE A  61
ALA A 111
 None
 1.35A 5ieoA-4kd6A:
undetectable		 5ieoA-4kd6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4kd6 ENOYL-COA
HYDRATASE/ISOMERASE
(Paraburkholderia
graminis) 		3 / 3 GLN A  65
TRP A  81
VAL A  82
 None
 1.14A 6auuA-4kd6A:
0.6		 6auuA-4kd6A:
19.48