SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 7 HIS A 357
THR A  10
ASN A   4
LEU A  75
 None
 1.12A 1qzrB-4kdsA:
undetectable		 1qzrB-4kdsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 7 LYS A 317
GLU A 277
ALA A 332
LEU A 160
 None
 1.08A 1sn0B-4kdsA:
undetectable
1sn0D-4kdsA:
undetectable		 1sn0B-4kdsA:
15.49
1sn0D-4kdsA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		3 / 3 TYR A  34
ARG A  73
GLN A 112
 None
 0.93A 1tw4A-4kdsA:
undetectable		 1tw4A-4kdsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		3 / 3 MET A 287
ASN A  28
GLN A 316
 None
 0.92A 1xoqB-4kdsA:
undetectable		 1xoqB-4kdsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		5 / 12 LEU A 269
GLU A 325
GLY A 326
ASN A 323
ALA A 329
 None
 1.06A 2bm9B-4kdsA:
undetectable		 2bm9B-4kdsA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		5 / 12 GLN A 316
ALA A  37
PHE A 366
ASN A 161
LEU A  87
 None
 1.41A 3aodC-4kdsA:
undetectable		 3aodC-4kdsA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 5 VAL A 220
LEU A 267
ILE A 218
LEU A 230
 None
 0.86A 4mghA-4kdsA:
undetectable		 4mghA-4kdsA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		5 / 12 ALA A 335
ILE A 336
ILE A 303
LEU A 309
GLN A 307
 None
 1.07A 4r3aA-4kdsA:
undetectable		 4r3aA-4kdsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 7 PHE A  17
LEU A 248
VAL A 241
PHE A 352
 None
 0.99A 4wnvD-4kdsA:
undetectable		 4wnvD-4kdsA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 6 THR A 155
SER A 147
LEU A 146
LEU A 127
 None
 0.82A 4wozA-4kdsA:
undetectable
4wozB-4kdsA:
undetectable		 4wozA-4kdsA:
22.84
4wozB-4kdsA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 8 ALA A 331
ASN A 161
HIS A 164
THR A 138
 None
 1.08A 5db5A-4kdsA:
undetectable
5db5B-4kdsA:
undetectable		 5db5A-4kdsA:
22.45
5db5B-4kdsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		3 / 3 LEU A 337
PHE A 120
ILE A 336
 None
 0.72A 5dzk1-4kdsA:
undetectable
5dzkF-4kdsA:
undetectable
5dzkM-4kdsA:
undetectable		 5dzk1-4kdsA:
2.35
5dzkF-4kdsA:
20.92
5dzkM-4kdsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 7 ILE A 356
HIS A 164
LEU A 163
ALA A 331
 None
 0.96A 5hrqE-4kdsA:
undetectable
5hrqF-4kdsA:
undetectable
5hrqJ-4kdsA:
undetectable		 5hrqE-4kdsA:
4.15
5hrqF-4kdsA:
7.63
5hrqJ-4kdsA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		5 / 12 LEU A 107
LEU A  55
LEU A  59
PHE A 111
ALA A 335
 None
 1.37A 5ieoA-4kdsA:
undetectable		 5ieoA-4kdsA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 4 GLN A   6
GLN A   9
PRO A  33
ALA A  37
 None
 1.49A 5odcA-4kdsA:
undetectable
5odcG-4kdsA:
undetectable		 5odcA-4kdsA:
18.59
5odcG-4kdsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 5 PRO A  33
ALA A  37
GLN A   6
GLN A   9
 None
 1.49A 5odcA-4kdsA:
undetectable
5odcG-4kdsA:
undetectable		 5odcA-4kdsA:
18.59
5odcG-4kdsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 5 LEU A  87
LEU A 163
MET A  42
GLN A 112
 None
 1.36A 5uc3A-4kdsA:
undetectable		 5uc3A-4kdsA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 7 ILE A  39
LEU A 337
THR A  51
ARG A 302
 None
None
None
SO4  A 401 (-2.6A)
 0.96A 5vc0A-4kdsA:
undetectable		 5vc0A-4kdsA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		5 / 10 VAL A 134
GLY A  90
LEU A 315
ILE A  39
ALA A 332
 None
 1.08A 5vm8B-4kdsA:
undetectable		 5vm8B-4kdsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 5 GLN A 307
THR A 304
THR A  51
LEU A 337
 None
 1.42A 6aphA-4kdsA:
undetectable		 6aphA-4kdsA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 4 GLN A 307
THR A 304
THR A  51
LEU A 337
 None
 1.42A 6f3mA-4kdsA:
undetectable		 6f3mA-4kdsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Oncorhynchus
mykiss) 		4 / 4 GLN A 307
THR A 304
THR A  51
LEU A 337
 None
 1.42A 6f3mC-4kdsA:
undetectable		 6f3mC-4kdsA:
20.25