SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		3 / 3 LYS A  15
ASP A  94
ASN A  67
 GSH  A 301 ( 4.4A)
None
None
 1.08A 2bm9A-4kdxA:
undetectable		 2bm9A-4kdxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 7 ILE A 169
LEU A 173
TYR A 198
ARG A 195
 None
 1.01A 3ag2N-4kdxA:
undetectable
3ag2W-4kdxA:
undetectable		 3ag2N-4kdxA:
17.55
3ag2W-4kdxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 7 ILE A 169
LEU A 173
TYR A 198
ARG A 195
 None
 1.05A 3ag4N-4kdxA:
undetectable
3ag4W-4kdxA:
undetectable		 3ag4N-4kdxA:
17.55
3ag4W-4kdxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 7 LEU A 192
ILE A  97
LEU A 160
SER A 159
 None
 0.72A 3r9vA-4kdxA:
2.1
3r9vB-4kdxA:
undetectable		 3r9vA-4kdxA:
22.22
3r9vB-4kdxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 6 ILE A 169
LEU A 173
TYR A 198
ARG A 195
 None
 1.03A 3wg7A-4kdxA:
undetectable
3wg7J-4kdxA:
undetectable		 3wg7A-4kdxA:
17.55
3wg7J-4kdxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 6 ALA A 111
LEU A 115
VAL A 116
GLU A 174
 None
 0.93A 4g24A-4kdxA:
3.3		 4g24A-4kdxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		5 / 12 GLY A  75
GLY A  79
LEU A  73
LEU A  23
ALA A  85
 None
 1.16A 4lg1C-4kdxA:
undetectable		 4lg1C-4kdxA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		5 / 12 GLY A  75
ALA A  74
GLY A  78
GLY A  79
LEU A  82
 None
 0.91A 4o3fA-4kdxA:
undetectable		 4o3fA-4kdxA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 6 ILE A 169
LEU A 173
TYR A 198
ARG A 195
 None
 0.97A 5b1aN-4kdxA:
undetectable
5b1aW-4kdxA:
undetectable		 5b1aN-4kdxA:
17.55
5b1aW-4kdxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 7 ILE A 153
GLN A 145
VAL A 142
ILE A 169
 None
 1.01A 6cduF-4kdxA:
3.8
6cduG-4kdxA:
3.8		 6cduF-4kdxA:
20.86
6cduG-4kdxA:
20.86