SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4keg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.94A 1e06A-4kegA:
undetectable		 1e06A-4kegA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A1135
LEU A1060
LEU A1059
ILE A1067
GLY A1066
 None
 1.21A 1g50B-4kegA:
undetectable		 1g50B-4kegA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 LEU A1135
LEU A1060
LEU A1059
ILE A1067
GLY A1066
 None
 1.21A 1g50C-4kegA:
undetectable		 1g50C-4kegA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A1054
GLY A1046
THR A1045
LEU A1231
LEU A1234
 None
 0.85A 1jipA-4kegA:
undetectable		 1jipA-4kegA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A  82
THR A  80
GLU A 274
 None
 0.86A 1pj7A-4kegA:
undetectable		 1pj7A-4kegA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A1161
LEU A1120
ILE A1242
LEU A1246
THR A1160
 None
 1.46A 1tdrB-4kegA:
undetectable		 1tdrB-4kegA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.19A 1wopA-4kegA:
undetectable		 1wopA-4kegA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LEU A1226
LEU A1055
SER A1056
LEU A1115
 None
 1.11A 1ya3A-4kegA:
undetectable		 1ya3A-4kegA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 LEU A1204
LEU A1207
LEU A1139
LEU A1151
 None
 0.90A 2ab2B-4kegA:
undetectable		 2ab2B-4kegA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 162
GLY A 165
GLY A 166
ALA A 188
GLN A 365
 None
 1.06A 2c49A-4kegA:
undetectable		 2c49A-4kegA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A 303
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 None
 1.21A 2h42A-4kegA:
undetectable		 2h42A-4kegA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
None
MG  A1302 (-4.7A)
MG  A1302 (-3.6A)
 1.08A 2q6oA-4kegA:
undetectable		 2q6oA-4kegA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-4kegA:
undetectable		 2ve3A-4kegA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
 None
None
None
BOG  A1301 ( 4.1A)
None
 1.01A 3a51C-4kegA:
undetectable		 3a51C-4kegA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A1065
LEU A1068
LEU A1071
LEU A1157
LEU A1116
 None
 1.19A 3d90B-4kegA:
undetectable		 3d90B-4kegA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A 290
LEU A  43
LEU A  20
LEU A  76
 None
 0.92A 3g8iA-4kegA:
undetectable		 3g8iA-4kegA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.33A 3gv1A-4kegA:
undetectable
3gv1C-4kegA:
undetectable		 3gv1A-4kegA:
13.02
3gv1C-4kegA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.31A 3gv1A-4kegA:
undetectable
3gv1B-4kegA:
undetectable		 3gv1A-4kegA:
13.02
3gv1B-4kegA:
13.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 GLU A 153
TYR A 155
MET A 330
TRP A 340
 None
 0.73A 3jyrA-4kegA:
53.5		 3jyrA-4kegA:
64.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A1135
LEU A1157
SER A1186
VAL A1131
 None
 0.92A 3ozkB-4kegA:
undetectable		 3ozkB-4kegA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 11 GLY A 300
ALA A 301
VAL A 259
GLY A 260
THR A  93
PRO A 107
 None
 1.32A 3ufnA-4kegA:
undetectable		 3ufnA-4kegA:
11.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 None
 0.35A 3vfjA-4kegA:
59.7		 3vfjA-4kegA:
77.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.98A 4n48A-4kegA:
undetectable		 4n48A-4kegA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 GLY A1221
LEU A1059
ILE A1159
LEU A1177
 None
 0.87A 4o8fA-4kegA:
undetectable		 4o8fA-4kegA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-4kegA:
undetectable		 4or0B-4kegA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A1120
ILE A1242
LEU A1234
LEU A1055
ALA A1054
 None
 1.05A 4p65F-4kegA:
undetectable
4p65H-4kegA:
undetectable
4p65K-4kegA:
undetectable
4p65L-4kegA:
undetectable		 4p65F-4kegA:
4.98
4p65H-4kegA:
4.98
4p65K-4kegA:
2.59
4p65L-4kegA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 GLY A1221
VAL A1223
THR A1181
VAL A1219
LEU A1157
 None
 1.29A 4yb6A-4kegA:
2.1
4yb6E-4kegA:
2.2		 4yb6A-4kegA:
20.85
4yb6E-4kegA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 GLY A1221
VAL A1223
THR A1181
VAL A1219
LEU A1157
 None
 1.30A 4yb6B-4kegA:
2.4
4yb6C-4kegA:
2.3		 4yb6B-4kegA:
20.85
4yb6C-4kegA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A1157
GLY A1221
VAL A1223
THR A1181
VAL A1219
 None
 1.29A 4yb6B-4kegA:
2.4
4yb6F-4kegA:
1.8		 4yb6B-4kegA:
20.85
4yb6F-4kegA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ILE A1067
GLU A1229
GLY A1062
GLY A1063
 None
 0.73A 5a06B-4kegA:
undetectable		 5a06B-4kegA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A1135
LEU A1157
SER A1186
VAL A1131
 None
 1.00A 5a6iA-4kegA:
undetectable		 5a6iA-4kegA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 None
 0.81A 6b58A-4kegA:
undetectable		 6b58A-4kegA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A1234
ILE A1163
PHE A1252
VAL A1253
LEU A1059
 None
 1.21A 6djzA-4kegA:
undetectable		 6djzA-4kegA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A1234
VAL A1131
LEU A1055
LEU A1059
 None
 0.72A 6g9bA-4kegA:
undetectable
6g9bB-4kegA:
undetectable		 6g9bA-4kegA:
9.67
6g9bB-4kegA:
11.43