SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kf5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 4kf5 FLUORESCENT PROTEIN
GFP1-9
FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct;
synthetic
construct) 		4 / 7 ASP C 173
HIS A  81
GLY C 210
GLY C 211
 None
 0.96A 1ekjE-4kf5C:
undetectable
1ekjF-4kf5C:
undetectable		 1ekjE-4kf5C:
21.51
1ekjF-4kf5C:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		4 / 5 PRO C 152
LEU C 157
THR C 147
ARG C 260
 None
 0.94A 1i2wA-4kf5C:
undetectable		 1i2wA-4kf5C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		4 / 4 THR C 106
GLY C 102
ASP C 101
ALA C 215
 None
 1.26A 1sg9A-4kf5C:
undetectable		 1sg9A-4kf5C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		4 / 4 LEU C 229
LEU C  85
SER C  86
LEU C  83
 None
 0.96A 1ya3A-4kf5C:
undetectable		 1ya3A-4kf5C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 4kf5 FLUORESCENT PROTEIN
GFP1-9
(synthetic
construct) 		3 / 3 ASN A 170
LEU A 141
HIS A 169
 None
 0.81A 2q6fB-4kf5A:
undetectable		 2q6fB-4kf5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4kf5 FLUORESCENT PROTEIN
GFP1-9
(synthetic
construct) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.1A)
None
None
 1.21A 3t3rB-4kf5A:
undetectable		 3t3rB-4kf5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4kf5 FLUORESCENT PROTEIN
GFP1-9
(synthetic
construct) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.1A)
None
None
 1.25A 3t3rC-4kf5A:
undetectable		 3t3rC-4kf5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4kf5 FLUORESCENT PROTEIN
GFP1-9
(synthetic
construct) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.1A)
None
None
 1.19A 3t3rD-4kf5A:
undetectable		 3t3rD-4kf5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		5 / 12 HIS C  75
GLY C 259
GLY C 159
GLU C 216
ASN C 162
 None
 1.17A 3v3oB-4kf5C:
undetectable		 3v3oB-4kf5C:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		5 / 12 PHE C  56
GLN C 253
LEU C  46
VAL C  48
ILE C  29
 None
CH6  C  66 ( 4.7A)
None
None
None
 1.09A 4k38B-4kf5C:
undetectable		 4k38B-4kf5C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		5 / 12 PHE C  56
GLN C 253
LEU C  46
VAL C  48
ILE C  29
 None
CH6  C  66 ( 4.7A)
None
None
None
 1.16A 4k39A-4kf5C:
undetectable		 4k39A-4kf5C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		4 / 8 TRP C 143
ILE C 161
GLU C 148
GLN C 163
 CH6  C  66 ( 4.7A)
CH6  C  66 ( 4.9A)
None
CH6  C  66 ( 3.5A)
 0.93A 4mj8A-4kf5C:
undetectable		 4mj8A-4kf5C:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		3 / 3 LYS C 222
ARG C  95
VAL C  96
 None
CH6  C  66 ( 2.5A)
None
 0.77A 4x3uA-4kf5C:
undetectable
4x3uB-4kf5C:
undetectable		 4x3uA-4kf5C:
16.81
4x3uB-4kf5C:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		3 / 3 TYR C 120
TYR C  82
SER C  86
 CH6  C  66 ( 4.3A)
None
None
 1.01A 5iktB-4kf5C:
undetectable		 5iktB-4kf5C:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4kf5 FLUORESCENT PROTEIN
GFP1-9
(synthetic
construct) 		3 / 3 LYS A 140
ASN A 135
SER A 175
 None
 1.20A 5yw0A-4kf5A:
undetectable		 5yw0A-4kf5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4kf5 FLUORESCENT PROTEIN
GFP1-9
(synthetic
construct) 		5 / 12 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CRO  A  66 ( 4.2A)
None
None
None
CRO  A  66 ( 4.5A)
 1.19A 6bbsA-4kf5A:
undetectable		 6bbsA-4kf5A:
18.00