SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		5 / 12 GLY A1627
ILE A1754
LEU A1746
VAL A1742
LEU A1667
 None
 1.20A 1r30A-4kf8A:
undetectable		 1r30A-4kf8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		5 / 12 GLY A1627
ILE A1754
LEU A1746
VAL A1742
LEU A1667
 None
 1.20A 1r30B-4kf8A:
undetectable		 1r30B-4kf8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		3 / 3 ALA A1653
VAL A1643
TRP A1659
 None
 0.89A 1tkqA-4kf8A:
undetectable		 1tkqA-4kf8A:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		5 / 12 LEU A1488
LEU A1484
LEU A1480
LEU A1513
THR A1491
 None
 1.24A 1zucB-4kf8A:
undetectable		 1zucB-4kf8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		5 / 11 LEU A1455
VAL A1558
CYH A1555
PHE A1485
LEU A1484
 None
 1.41A 3bgrA-4kf8A:
undetectable
3bgrB-4kf8A:
undetectable		 3bgrA-4kf8A:
20.77
3bgrB-4kf8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		4 / 5 THR A1549
LEU A1605
GLU A1601
LYS A1661
 None
 1.43A 4a3pA-4kf8A:
undetectable		 4a3pA-4kf8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		5 / 12 VAL A1522
ALA A1550
LEU A1605
LEU A1606
LEU A1556
 None
 1.13A 4i1rA-4kf8A:
undetectable		 4i1rA-4kf8A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		5 / 12 PRO A1665
PHE A1585
LEU A1608
GLY A1651
MET A1638
 None
 1.30A 4mubA-4kf8A:
undetectable		 4mubA-4kf8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		5 / 9 ALA A1660
ALA A1657
LEU A1785
SER A1695
LEU A1692
 None
 1.37A 4or0A-4kf8A:
undetectable		 4or0A-4kf8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		4 / 4 LEU A1607
MET A1572
ILE A1670
LEU A1613
 None
 1.07A 5nfpA-4kf8A:
undetectable		 5nfpA-4kf8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		5 / 12 ALA A1635
LEU A1692
ILE A1658
PHE A1585
LEU A1664
 None
 1.25A 5uanB-4kf8A:
undetectable		 5uanB-4kf8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4kf8 NUP188
(Thermothelomyces
thermophila) 		3 / 3 ASP A1589
LEU A1634
ARG A1639
 None
 0.73A 7dfrA-4kf8A:
undetectable		 7dfrA-4kf8A:
18.40