SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kf9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		3 / 3 ASP A 278
ARG A  54
ARG A  53
 None
GSH  A 405 (-3.9A)
GSH  A 405 (-3.5A)
 0.67A 2j9dA-4kf9A:
undetectable
2j9dC-4kf9A:
undetectable		 2j9dA-4kf9A:
13.73
2j9dC-4kf9A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 6 MET A 230
VAL A  34
ILE A 238
LEU A   8
 None
 0.59A 3hegA-4kf9A:
undetectable		 3hegA-4kf9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 9 HIS A  10
LEU A   8
PRO A  56
LEU A  58
THR A  68
 None
None
None
None
GSH  A 405 (-3.0A)
 1.05A 3q1eB-4kf9A:
undetectable
3q1eD-4kf9A:
undetectable		 3q1eB-4kf9A:
15.48
3q1eD-4kf9A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 9 HIS A  10
LEU A   8
PRO A  56
THR A  68
HIS A 224
 None
None
None
GSH  A 405 (-3.0A)
ZN  A 401 ( 3.2A)
 0.91A 3q1eB-4kf9A:
undetectable
3q1eD-4kf9A:
undetectable		 3q1eB-4kf9A:
15.48
3q1eD-4kf9A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 ALA A 185
VAL A 189
ASP A 186
LEU A 165
 None
 1.11A 4e7gA-4kf9A:
undetectable		 4e7gA-4kf9A:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KF9_A_ACTA406_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 TYR A  11
PHE A 105
ARG A 137
MET A 140
 ACT  A 408 ( 4.8A)
ACT  A 406 ( 4.9A)
GSH  A 405 (-3.5A)
GSH  A 405 ( 3.4A)
 0.00A 4kf9A-4kf9A:
55.5		 4kf9A-4kf9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		3 / 3 GLU A  18
ARG A  21
HIS A 224
 ZN  A 401 ( 1.9A)
ACT  A 407 (-3.6A)
ZN  A 401 ( 3.2A)
 0.00A 4kf9A-4kf9A:
55.5		 4kf9A-4kf9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		6 / 6 TYR A  11
THR A  13
PRO A  15
PHE A 133
ARG A 137
PHE A 195
 ACT  A 408 ( 4.8A)
ACT  A 408 (-4.7A)
GSH  A 405 ( 4.1A)
ACT  A 408 (-4.7A)
GSH  A 405 (-3.5A)
ACT  A 408 (-4.4A)
 0.00A 4kf9A-4kf9A:
55.5		 4kf9A-4kf9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 6 HIS A   9
LEU A   8
CYH A  66
HIS A  10
 None
 1.27A 5hrqD-4kf9A:
undetectable
5hrqG-4kf9A:
undetectable
5hrqH-4kf9A:
undetectable		 5hrqD-4kf9A:
6.77
5hrqG-4kf9A:
4.26
5hrqH-4kf9A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		3 / 3 THR A 200
THR A  13
LEU A 125
 None
ACT  A 408 (-4.7A)
None
 0.59A 5m66D-4kf9A:
undetectable		 5m66D-4kf9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 SER A 110
ALA A 107
GLN A 159
THR A 157
 None
 1.07A 5n0rA-4kf9A:
undetectable		 5n0rA-4kf9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 SER A 110
ALA A 107
GLN A 159
THR A 157
 None
 1.08A 5n0sA-4kf9A:
undetectable		 5n0sA-4kf9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 5 SER A 110
ALA A 107
GLN A 159
THR A 157
 None
 1.09A 5n0tA-4kf9A:
undetectable		 5n0tA-4kf9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 SER A 110
ALA A 107
GLN A 159
THR A 157
 None
 1.05A 5n0wA-4kf9A:
undetectable		 5n0wA-4kf9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 5 SER A 110
ALA A 107
GLN A 159
THR A 157
 None
 1.04A 5n0wB-4kf9A:
undetectable		 5n0wB-4kf9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 SER A 110
ALA A 107
GLN A 159
THR A 157
 None
 1.08A 5n0xA-4kf9A:
undetectable		 5n0xA-4kf9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 5 SER A 110
ALA A 107
GLN A 159
THR A 157
 None
 1.05A 5n4iA-4kf9A:
undetectable		 5n4iA-4kf9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 10 VAL A 270
ALA A 272
PHE A 308
VAL A 280
THR A 273
 None
 1.38A 6aogA-4kf9A:
undetectable		 6aogA-4kf9A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 10 VAL A 270
ALA A 272
PHE A 308
VAL A 280
THR A 273
 None
 1.38A 6aogB-4kf9A:
undetectable		 6aogB-4kf9A:
14.59