SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 11 ASP A 147
SER A 188
LEU A 189
PRO A 179
ILE A 193
 None
 1.20A 1dg5A-4kfvA:
undetectable		 1dg5A-4kfvA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		4 / 8 GLU A 144
HIS A 155
LEU A 160
LEU A 162
 None
 0.94A 1hwiB-4kfvA:
undetectable		 1hwiB-4kfvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		4 / 8 GLU A 144
HIS A 155
LEU A 160
LEU A 162
 None
 0.91A 1hwiD-4kfvA:
undetectable		 1hwiD-4kfvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		4 / 8 GLU A 144
HIS A 155
LEU A 160
LEU A 162
 None
 0.91A 1hwiC-4kfvA:
undetectable		 1hwiC-4kfvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		4 / 7 PHE A 148
VAL A 177
VAL A 114
ILE A 135
 None
 0.90A 1p7rA-4kfvA:
undetectable		 1p7rA-4kfvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 10 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.36A 3fhjE-4kfvA:
undetectable		 3fhjE-4kfvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 9 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.40A 3fi0A-4kfvA:
undetectable		 3fi0A-4kfvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 9 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.45A 3fi0C-4kfvA:
undetectable		 3fi0C-4kfvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 9 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.40A 3fi0H-4kfvA:
undetectable		 3fi0H-4kfvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 9 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.39A 3fi0K-4kfvA:
undetectable		 3fi0K-4kfvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 9 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.49A 3fi0L-4kfvA:
undetectable		 3fi0L-4kfvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 9 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.35A 3fi0M-4kfvA:
undetectable		 3fi0M-4kfvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 9 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.44A 3fi0N-4kfvA:
undetectable		 3fi0N-4kfvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 9 GLN A  28
VAL A  21
ILE A  39
VAL A  70
VAL A  81
 None
 1.43A 3fi0O-4kfvA:
undetectable		 3fi0O-4kfvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 HIS A 113
PHE A 148
PHE A 149
 None
 0.72A 3lk0D-4kfvA:
undetectable		 3lk0D-4kfvA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 HIS A 199
PHE A 148
PHE A 149
 None
 0.50A 3lk0D-4kfvA:
undetectable		 3lk0D-4kfvA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 LYS A 158
PRO A 159
LEU A 160
 None
 0.86A 3tpxE-4kfvA:
undetectable		 3tpxE-4kfvA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 12 GLY A 192
GLY A 194
ALA A 123
PHE A 149
LEU A 189
 None
 1.19A 3vywA-4kfvA:
undetectable		 3vywA-4kfvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 12 GLY A 192
GLY A 194
ALA A 123
PHE A 149
LEU A 189
 None
 1.19A 3vywB-4kfvA:
undetectable		 3vywB-4kfvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 12 GLY A 192
GLY A 194
ALA A 123
PHE A 149
LEU A 189
 None
 1.20A 3vywD-4kfvA:
undetectable		 3vywD-4kfvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		4 / 6 HIS A  17
GLU A  33
LEU A 162
TYR A 134
 ZN  A 301 ( 3.4A)
None
None
None
 1.00A 5igiA-4kfvA:
undetectable		 5igiA-4kfvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 VAL A 111
LYS A  74
MET A  76
 None
 1.09A 5nknA-4kfvA:
undetectable		 5nknA-4kfvA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 12 VAL A 117
ASP A 116
ALA A 123
SER A 121
LEU A 162
 None
 1.20A 6ew0F-4kfvA:
undetectable		 6ew0F-4kfvA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1
(Rattus
norvegicus) 		5 / 12 VAL A 117
ASP A 116
ALA A 123
SER A 121
LEU A 162
 None
 1.21A 6ew0G-4kfvA:
undetectable		 6ew0G-4kfvA:
15.71