SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 4kfz LMO-2
(Homo
sapiens) 		5 / 12 TYR A  41
GLY A  68
GLU A  66
ARG A  63
GLU A  52
 None
 1.17A 1agmA-4kfzA:
undetectable		 1agmA-4kfzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 4kfz LMO-2
(Homo
sapiens) 		5 / 12 TYR A  41
GLY A  68
GLU A  66
ARG A  63
GLU A  52
 None
 1.17A 1agmA-4kfzA:
undetectable		 1agmA-4kfzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4kfz ANTI-LMO2 VH
(Homo
sapiens) 		4 / 7 SER C  56
SER C  57
SER C  52
ASN C  54
 None
 1.06A 2cmlA-4kfzC:
undetectable		 2cmlA-4kfzC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4kfz ANTI-LMO2 VH
(Homo
sapiens) 		4 / 8 SER C  56
SER C  57
SER C  52
ASN C  54
 None
 1.07A 2cmlB-4kfzC:
undetectable		 2cmlB-4kfzC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4kfz ANTI-LMO2 VH
(Homo
sapiens) 		4 / 8 SER C  56
SER C  57
SER C  52
ASN C  54
 None
 1.06A 2cmlC-4kfzC:
undetectable		 2cmlC-4kfzC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4kfz ANTI-LMO2 VH
(Homo
sapiens) 		4 / 8 SER C  56
SER C  57
SER C  52
ASN C  54
 None
 1.14A 2cmlD-4kfzC:
undetectable		 2cmlD-4kfzC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 4kfz LMO-2
(Homo
sapiens) 		5 / 12 TYR A  41
GLY A  68
GLU A  66
ARG A  63
GLU A  52
 None
 1.18A 2f6dA-4kfzA:
undetectable		 2f6dA-4kfzA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4kfz LMO-2
(Homo
sapiens) 		3 / 3 TYR A  84
GLY A  89
ASP A  91
 None
 0.69A 3ou6C-4kfzA:
undetectable		 3ou6C-4kfzA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4kfz ANTI-LMO2 VH
(Homo
sapiens) 		5 / 12 ALA C  24
SER C  28
MET C  34
ARG C  72
ASN C  77
 None
 0.88A 3qxtA-4kfzC:
20.4		 3qxtA-4kfzC:
62.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4kfz ANTI-LMO2 VH
(Homo
sapiens) 		6 / 11 VAL C   2
ALA C  24
SER C  28
MET C  34
ARG C  72
ASN C  74
 None
 0.90A 3qxvC-4kfzC:
20.1		 3qxvC-4kfzC:
61.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4kfz ANTI-LMO2 VH
LMO-2
(Homo
sapiens) 		4 / 8 PHE C  27
SER C  32
GLU A  52
ASP A  53
 None
 1.13A 4qb9D-4kfzC:
undetectable		 4qb9D-4kfzC:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4kfz LMO-2
ANTI-LMO2 VH
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR C  59
ALA A 103
TYR A 104
 None
 0.86A 5uunB-4kfzC:
undetectable		 5uunB-4kfzC:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4kfz ANTI-LMO2 VH
(Homo
sapiens) 		3 / 3 TYR C  60
GLY C  66
THR C  69
 None
 0.12A 6cjkB-4kfzC:
18.5		 6cjkB-4kfzC:
60.80