SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kg7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 THR A 297
GLY A 285
SER A 382
GLY A 300
 None
 0.77A 1d0vA-4kg7A:
2.7		 1d0vA-4kg7A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 PRO A 392
VAL A 284
VAL A 287
GLY A 285
LEU A 370
 None
 1.41A 1lwcA-4kg7A:
1.7		 1lwcA-4kg7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 284
GLY A 285
THR A 340
VAL A 203
ILE A 200
 None
 1.03A 1phgA-4kg7A:
undetectable		 1phgA-4kg7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 286
LEU A 152
GLY A 309
PHE A 296
TYR A 342
 None
 1.14A 1qabF-4kg7A:
undetectable		 1qabF-4kg7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.86A 1rxcB-4kg7A:
undetectable		 1rxcB-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.98A 1rxcC-4kg7A:
2.7		 1rxcC-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.93A 1rxcD-4kg7A:
undetectable		 1rxcD-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.87A 1rxcE-4kg7A:
3.0		 1rxcE-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.88A 1rxcF-4kg7A:
2.6		 1rxcF-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.90A 1rxcI-4kg7A:
2.6		 1rxcI-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.86A 1rxcK-4kg7A:
undetectable		 1rxcK-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.88A 1rxcL-4kg7A:
undetectable		 1rxcL-4kg7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 THR A 297
GLY A 309
ALA A 343
VAL A 303
 None
 0.84A 2a1hA-4kg7A:
undetectable
2a1hB-4kg7A:
undetectable		 2a1hA-4kg7A:
21.81
2a1hB-4kg7A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 327
LEU A 337
GLY A 127
SER A 314
ASP A 122
 None
 1.02A 2bm9B-4kg7A:
undetectable		 2bm9B-4kg7A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 327
LEU A 337
GLY A 127
SER A 314
ASP A 122
 None
 1.01A 2br4D-4kg7A:
undetectable		 2br4D-4kg7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 346
ALA A 235
SER A 201
ALA A 345
GLY A 237
 None
 1.23A 2igtC-4kg7A:
2.3		 2igtC-4kg7A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A 354
VAL A 231
ASP A 229
VAL A 197
 None
 0.97A 2qbnA-4kg7A:
undetectable		 2qbnA-4kg7A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 143
SER A 314
LEU A 152
VAL A  98
ALA A 345
 None
 1.25A 3u9fD-4kg7A:
undetectable
3u9fE-4kg7A:
undetectable		 3u9fD-4kg7A:
21.16
3u9fE-4kg7A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 369
PHE A 358
PRO A 359
 None
 0.78A 3zoaB-4kg7A:
undetectable		 3zoaB-4kg7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.95A 4e1vA-4kg7A:
2.1		 4e1vA-4kg7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.89A 4e1vB-4kg7A:
undetectable		 4e1vB-4kg7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.86A 4e1vC-4kg7A:
undetectable		 4e1vC-4kg7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.87A 4e1vD-4kg7A:
undetectable		 4e1vD-4kg7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.91A 4e1vE-4kg7A:
undetectable		 4e1vE-4kg7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.96A 4e1vG-4kg7A:
2.2		 4e1vG-4kg7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 291
GLN A 375
VAL A 287
PRO A 308
 None
 0.88A 4e1vH-4kg7A:
2.0		 4e1vH-4kg7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 9 TYR A 113
ALA A 190
ARG A 151
ILE A 153
ILE A 155
 None
 0.97A 4oknB-4kg7A:
3.8		 4oknB-4kg7A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A 345
ASN A 106
VAL A 107
GLY A 136
VAL A  98
 None
 1.24A 4r20B-4kg7A:
undetectable		 4r20B-4kg7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 LEU A 353
PRO A 392
VAL A 390
ILE A 305
ALA A 387
GLY A 349
 None
 1.40A 5j2tC-4kg7A:
undetectable		 5j2tC-4kg7A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 265
PRO A 255
GLY A 300
PRO A 301
 None
 1.11A 5kf8A-4kg7A:
undetectable		 5kf8A-4kg7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 265
PRO A 255
GLY A 300
PRO A 301
 None
 1.10A 5kgpA-4kg7A:
undetectable		 5kgpA-4kg7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 265
PRO A 255
GLY A 300
PRO A 301
 None
 1.10A 5kgpB-4kg7A:
undetectable		 5kgpB-4kg7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  91
ALA A 235
VAL A 130
GLY A 132
ALA A 131
 None
 1.07A 5kirA-4kg7A:
undetectable		 5kirA-4kg7A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 127
GLY A 125
THR A  96
VAL A  93
VAL A 315
 None
 1.20A 5kocB-4kg7A:
undetectable		 5kocB-4kg7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A 324
GLY A 127
GLY A 125
THR A  96
VAL A  93
 None
 1.06A 5kocB-4kg7A:
undetectable		 5kocB-4kg7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 287
GLY A 309
SER A 341
ALA A 306
SER A 294
 None
 1.21A 5x6yC-4kg7A:
1.6		 5x6yC-4kg7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 232
LEU A 202
GLN A 157
PRO A 274
LEU A 221
 None
 1.23A 5xxiA-4kg7A:
undetectable		 5xxiA-4kg7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A  36
ASP A 192
VAL A 281
ILE A 232
ILE A 200
 None
 1.33A 5y80A-4kg7A:
undetectable		 5y80A-4kg7A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 9 VAL A 203
GLY A 127
VAL A 130
ASP A 124
GLY A 125
 None
 1.36A 5zniA-4kg7A:
2.8		 5zniA-4kg7A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ALA A 235
THR A 340
TYR A 342
PRO A 160
 None
 0.94A 6cduA-4kg7A:
undetectable
6cduE-4kg7A:
undetectable		 6cduA-4kg7A:
20.67
6cduE-4kg7A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PRO A 160
ALA A 235
THR A 340
TYR A 342
 None
 0.92A 6cduH-4kg7A:
undetectable
6cduI-4kg7A:
undetectable		 6cduH-4kg7A:
20.67
6cduI-4kg7A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 202
GLY A  97
GLY A 127
GLY A 132
TYR A 342
 None
 1.04A 6ce2B-4kg7A:
undetectable		 6ce2B-4kg7A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 131
GLY A 119
GLY A  97
SER A 116
VAL A 107
 None
 1.08A 6clxA-4kg7A:
undetectable		 6clxA-4kg7A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 PRO A 148
SER A  84
LEU A 152
ILE A 134
GLY A 349
 None
 1.29A 6dlzA-4kg7A:
6.1
6dlzD-4kg7A:
0.9		 6dlzA-4kg7A:
11.81
6dlzD-4kg7A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 134
GLY A 349
PRO A 148
SER A  84
LEU A 152
 None
 1.29A 6dlzB-4kg7A:
0.9
6dlzC-4kg7A:
6.0		 6dlzB-4kg7A:
11.81
6dlzC-4kg7A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 PRO A 148
SER A  84
LEU A 152
ILE A 134
GLY A 349
 None
 1.29A 6dm1A-4kg7A:
5.9
6dm1D-4kg7A:
0.9		 6dm1A-4kg7A:
11.81
6dm1D-4kg7A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 134
GLY A 349
PRO A 148
SER A  84
LEU A 152
 None
 1.29A 6dm1B-4kg7A:
5.6
6dm1C-4kg7A:
6.0		 6dm1B-4kg7A:
11.81
6dm1C-4kg7A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASN A 383
PRO A 301
GLN A 278
 None
 0.91A 6jnhA-4kg7A:
undetectable		 6jnhA-4kg7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASN A 383
PRO A 301
GLN A 278
 None
 0.93A 6jogA-4kg7A:
undetectable		 6jogA-4kg7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 122
SER A 314
SER A 324
 None
 0.68A 6mxtA-4kg7A:
undetectable		 6mxtA-4kg7A:
20.43