SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		3 / 3 VAL A 217
VAL A 215
TRP A 114
 None
 0.75A 1av2C-4kg8A:
undetectable
1av2D-4kg8A:
undetectable		 1av2C-4kg8A:
11.21
1av2D-4kg8A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		5 / 12 GLY A 204
LEU A 180
LEU A 179
VAL A 215
ALA A 237
 None
 1.13A 1gseA-4kg8A:
undetectable		 1gseA-4kg8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		4 / 8 GLY A 204
LEU A 180
VAL A 215
PHE A 238
 None
 0.85A 1gsfA-4kg8A:
undetectable		 1gsfA-4kg8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		4 / 8 GLY A 204
LEU A 180
VAL A 215
PHE A 238
 None
 0.85A 1gsfB-4kg8A:
undetectable		 1gsfB-4kg8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		4 / 8 GLY A 204
LEU A 180
VAL A 215
PHE A 238
 None
 0.86A 1gsfC-4kg8A:
undetectable		 1gsfC-4kg8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		4 / 8 GLY A 204
LEU A 180
VAL A 215
PHE A 238
 None
 0.85A 1gsfD-4kg8A:
undetectable		 1gsfD-4kg8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		3 / 3 VAL A 217
VAL A 215
TRP A 114
 None
 0.73A 1w5uC-4kg8A:
undetectable
1w5uD-4kg8A:
undetectable		 1w5uC-4kg8A:
11.21
1w5uD-4kg8A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		3 / 3 VAL A 215
TRP A 114
VAL A 217
 None
 0.72A 2izqA-4kg8A:
undetectable
2izqB-4kg8A:
undetectable		 2izqA-4kg8A:
11.21
2izqB-4kg8A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		3 / 3 VAL A 217
VAL A 215
TRP A 114
 None
 0.76A 3l8lA-4kg8A:
undetectable
3l8lB-4kg8A:
undetectable		 3l8lA-4kg8A:
11.21
3l8lB-4kg8A:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14
(Homo
sapiens) 		3 / 3 VAL A 217
VAL A 215
TRP A 114
 None
 0.74A 3l8lC-4kg8A:
undetectable
3l8lD-4kg8A:
undetectable		 3l8lC-4kg8A:
11.21
3l8lD-4kg8A:
6.04