SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kgb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 11 ILE A  60
ASN A 270
GLY A  94
ASN A  69
GLY A  87
 None
 1.48A 1ho5A-4kgbA:
undetectable		 1ho5A-4kgbA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 ILE A 301
ILE A 434
LEU A 480
ILE A 448
ILE A 462
 None
 0.95A 1oipA-4kgbA:
undetectable		 1oipA-4kgbA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 GLY A 111
ASN A 341
SER A 339
ILE A 343
ILE A 360
 None
 1.16A 1q8jB-4kgbA:
undetectable		 1q8jB-4kgbA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 ASN A 113
GLY A  92
GLY A  94
ASP A  90
ASN A 223
 None
 1.14A 2zw9A-4kgbA:
undetectable		 2zw9A-4kgbA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		6 / 12 GLY A  56
ILE A 106
VAL A 105
GLY A  81
ILE A  53
ILE A 139
 None
 1.41A 3ekqA-4kgbA:
undetectable		 3ekqA-4kgbA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 8 LEU A 317
GLY A 420
ALA A 422
ILE A 435
 None
 0.76A 3jusA-4kgbA:
undetectable		 3jusA-4kgbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 8 LEU A 317
GLY A 420
ALA A 422
ILE A 435
 None
 0.76A 3jusA-4kgbA:
undetectable		 3jusA-4kgbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 GLY A 420
ASP A 424
ASN A 361
GLY A 363
ILE A 319
 None
 1.18A 3ku1G-4kgbA:
undetectable		 3ku1G-4kgbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 9 LEU A 482
PHE A 502
ILE A 495
ALA A 496
THR A 490
 None
 1.22A 3mdtA-4kgbA:
undetectable		 3mdtA-4kgbA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 10 PRO A 227
ASN A  84
GLY A  56
GLY A 133
ALA A 136
 None
 1.33A 3pp7B-4kgbA:
undetectable		 3pp7B-4kgbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		3 / 3 ASN A 361
ALA A 362
LYS A 364
 None
 1.00A 3runA-4kgbA:
undetectable		 3runA-4kgbA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 10 ILE A 197
SER A 108
ASN A  84
ILE A 139
ALA A 231
 None
 1.34A 3u6tA-4kgbA:
undetectable		 3u6tA-4kgbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 VAL A 400
ILE A 462
GLU A 438
GLU A 468
VAL A 474
 None
 1.32A 4a97B-4kgbA:
undetectable
4a97C-4kgbA:
undetectable		 4a97B-4kgbA:
22.11
4a97C-4kgbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 TYR A 109
GLY A  59
GLN A 132
ASN A  84
ILE A 360
 None
 1.24A 4azwA-4kgbA:
undetectable		 4azwA-4kgbA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 7 PHE A 201
PHE A 203
ALA A  45
LEU A  71
 None
 1.03A 4ejgA-4kgbA:
undetectable		 4ejgA-4kgbA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 LEU A  96
LEU A  71
ILE A  79
PHE A 203
LEU A  93
 None
 1.00A 4lmnA-4kgbA:
undetectable		 4lmnA-4kgbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 ASN A 408
LEU A 317
GLY A 318
THR A 436
THR A 393
 None
 1.15A 4o5fA-4kgbA:
undetectable
4o5fB-4kgbA:
undetectable		 4o5fA-4kgbA:
20.43
4o5fB-4kgbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 THR A 393
ASN A 408
LEU A 317
GLY A 318
THR A 436
 None
 1.17A 4o5fA-4kgbA:
undetectable
4o5fB-4kgbA:
undetectable		 4o5fA-4kgbA:
20.43
4o5fB-4kgbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 6 ASP A 380
THR A 151
PRO A 152
THR A 153
 None
 1.09A 4yoaA-4kgbA:
undetectable		 4yoaA-4kgbA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 ASN A 408
LEU A 317
GLY A 318
THR A 436
THR A 393
 None
 1.13A 5b8hA-4kgbA:
undetectable
5b8hB-4kgbA:
undetectable		 5b8hA-4kgbA:
21.19
5b8hB-4kgbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 THR A 393
ASN A 408
LEU A 317
GLY A 318
THR A 436
 None
 1.13A 5b8hA-4kgbA:
undetectable
5b8hB-4kgbA:
undetectable		 5b8hA-4kgbA:
21.19
5b8hB-4kgbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 4 SER A 381
THR A 393
ASP A 463
ASP A 424
 None
 1.35A 5vimA-4kgbA:
undetectable		 5vimA-4kgbA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 4 SER A 381
THR A 393
ASP A 463
ASP A 424
 None
 1.30A 5vimB-4kgbA:
undetectable		 5vimB-4kgbA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 5 PRO A 429
GLY A 430
THR A 431
LYS A 432
 None
 1.13A 5x23A-4kgbA:
undetectable		 5x23A-4kgbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 6 PRO A 429
GLY A 430
THR A 431
LYS A 432
 None
 1.01A 5x24A-4kgbA:
undetectable		 5x24A-4kgbA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		4 / 6 PRO A 429
GLY A 430
THR A 431
LYS A 432
 None
 1.04A 5xxiA-4kgbA:
undetectable		 5xxiA-4kgbA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE
(Drosophila
melanogaster) 		5 / 12 ASP A 380
PHE A 382
PHE A  58
ASN A  84
ASN A 341
 None
 1.34A 6mxtA-4kgbA:
undetectable		 6mxtA-4kgbA:
22.30