SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 ASP A  75
ARG A  28
ILE A  29
VAL A  70
 MG  A 302 (-2.8A)
None
None
None
 1.25A 3eigA-4kgkA:
undetectable		 3eigA-4kgkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 ILE A 100
VAL A  27
ILE A  79
ASN A  63
ILE A  64
 None
 1.18A 3kpcA-4kgkA:
undetectable		 3kpcA-4kgkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 100
VAL A  27
ILE A  79
ASN A  63
ILE A  64
 None
 1.16A 3kpdB-4kgkA:
undetectable		 3kpdB-4kgkA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN
(Bacillus
thuringiensis) 		4 / 8 ILE A  64
ALA A 105
VAL A  27
VAL A  70
 None
 0.80A 4jltA-4kgkA:
undetectable		 4jltA-4kgkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 200
GLY A 199
HIS A 221
GLU A 205
TYR A 232
 None
 1.42A 5igwA-4kgkA:
undetectable		 5igwA-4kgkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 MET A  23
LEU A  19
ILE A  64
SER A  91
GLY A  66
 None
 1.10A 6dm0B-4kgkA:
undetectable
6dm0C-4kgkA:
undetectable		 6dm0B-4kgkA:
16.88
6dm0C-4kgkA:
16.88