SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kh3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 11 THR A 116
THR A  61
LEU A  99
GLY A  87
VAL A  71
 None
 1.21A 1akdA-4kh3A:
undetectable		 1akdA-4kh3A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 9 GLY A 395
THR A 379
ALA A 380
LEU A 421
THR A 383
 None
 1.19A 2npnA-4kh3A:
undetectable		 2npnA-4kh3A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 ASP A 339
ALA A 338
VAL A 344
GLY A 322
GLY A 341
 None
 0.89A 2p16A-4kh3A:
undetectable		 2p16A-4kh3A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kh3 ANTIGEN 43
(Escherichia
coli) 		4 / 7 GLY A 395
GLY A 341
PHE A 372
PHE A 390
 None
 0.96A 2qwxA-4kh3A:
undetectable
2qwxB-4kh3A:
undetectable		 2qwxA-4kh3A:
18.50
2qwxB-4kh3A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		4 / 7 LEU A 470
SER A 473
THR A 454
VAL A 451
 None
 1.06A 2uz2A-4kh3A:
undetectable		 2uz2A-4kh3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLN A 225
GLY A 223
ASP A 222
ASN A 247
TYR A 207
 None
None
None
MLI  A 605 (-2.6A)
None
 1.12A 2zw9A-4kh3A:
undetectable		 2zw9A-4kh3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLN A 225
GLY A 223
ASP A 222
ASN A 247
TYR A 207
 None
None
None
MLI  A 605 (-2.6A)
None
 1.18A 2zw9B-4kh3A:
undetectable		 2zw9B-4kh3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 ILE A 219
VAL A 208
GLN A 225
VAL A 246
VAL A 255
 None
 1.16A 3iw1A-4kh3A:
undetectable		 3iw1A-4kh3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 TYR A 207
GLY A 194
ALA A 196
THR A 182
ILE A 184
 None
 1.38A 3ld6A-4kh3A:
undetectable		 3ld6A-4kh3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 TYR A 207
GLY A 194
ALA A 196
THR A 182
ILE A 184
 None
 1.38A 3ld6B-4kh3A:
undetectable		 3ld6B-4kh3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLY A 111
GLY A 109
ALA A 132
ALA A 113
LEU A  90
 MLI  A 604 ( 4.5A)
None
None
None
None
 1.05A 3p2kA-4kh3A:
undetectable		 3p2kA-4kh3A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 9 SER A  78
THR A  80
THR A  61
ASN A  60
GLY A  30
 None
 1.18A 3sfuA-4kh3A:
undetectable		 3sfuA-4kh3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 ILE A  82
GLY A  86
GLY A  87
THR A  80
GLY A  36
 None
 0.80A 3uboA-4kh3A:
undetectable		 3uboA-4kh3A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 ILE A  82
GLY A  86
GLY A  87
THR A  80
GLY A  36
 None
 0.77A 4e3aB-4kh3A:
undetectable		 4e3aB-4kh3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 9 ASP A 339
VAL A 344
GLY A 322
SER A 340
GLY A 357
 None
 1.25A 4mmeA-4kh3A:
undetectable		 4mmeA-4kh3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 9 ASP A 339
VAL A 344
GLY A 322
SER A 340
GLY A 357
 None
 1.26A 4mmeB-4kh3A:
undetectable		 4mmeB-4kh3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 9 ASP A 339
VAL A 344
GLY A 322
SER A 340
GLY A 357
 None
 1.22A 4mmfA-4kh3A:
undetectable		 4mmfA-4kh3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 9 ASP A 339
VAL A 344
GLY A 322
SER A 340
GLY A 357
 None
 1.24A 4mmfB-4kh3A:
undetectable		 4mmfB-4kh3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 10 LEU A 421
THR A 415
LEU A 435
LEU A 411
THR A 401
 None
 1.03A 4z91A-4kh3A:
undetectable
4z91B-4kh3A:
undetectable
4z91C-4kh3A:
undetectable
4z91D-4kh3A:
undetectable
4z91E-4kh3A:
undetectable		 4z91A-4kh3A:
21.07
4z91B-4kh3A:
21.07
4z91C-4kh3A:
21.07
4z91D-4kh3A:
21.07
4z91E-4kh3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLY A 177
GLY A 194
ALA A 196
ALA A 160
ILE A 126
 None
 1.22A 5bw4B-4kh3A:
undetectable		 5bw4B-4kh3A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLY A 212
GLY A 231
ALA A 233
ALA A 196
ILE A 173
 None
 1.21A 5bw4B-4kh3A:
undetectable		 5bw4B-4kh3A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		4 / 6 SER A  43
GLU A  45
GLY A 103
GLY A  87
 None
 0.94A 5cdnC-4kh3A:
undetectable
5cdnD-4kh3A:
undetectable		 5cdnC-4kh3A:
22.18
5cdnD-4kh3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 ASP A 312
ARG A 310
LEU A 277
ASN A 239
GLY A 260
 None
 1.14A 5k7uA-4kh3A:
undetectable		 5k7uA-4kh3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLY A  26
HIS A   6
VAL A   4
PHE A  23
VAL A  71
 MLI  A 601 (-3.2A)
None
None
None
None
 1.14A 5n0oA-4kh3A:
undetectable		 5n0oA-4kh3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLY A  26
HIS A   6
VAL A   4
PHE A  23
VAL A  71
 MLI  A 601 (-3.2A)
None
None
None
None
 1.13A 5n0rA-4kh3A:
undetectable		 5n0rA-4kh3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLY A  26
HIS A   6
VAL A   4
PHE A  23
VAL A  71
 MLI  A 601 (-3.2A)
None
None
None
None
 1.09A 5n0tA-4kh3A:
undetectable		 5n0tA-4kh3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 10 LEU A 449
GLY A 447
GLY A 445
LEU A 403
ALA A 428
 None
 0.99A 5o96C-4kh3A:
undetectable
5o96D-4kh3A:
undetectable		 5o96C-4kh3A:
19.17
5o96D-4kh3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 10 LEU A 449
GLY A 447
GLY A 445
LEU A 403
ALA A 428
 None
 0.92A 5o96E-4kh3A:
undetectable
5o96F-4kh3A:
undetectable		 5o96E-4kh3A:
19.17
5o96F-4kh3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 10 LEU A 449
GLY A 447
GLY A 445
LEU A 403
ALA A 428
 None
 0.95A 5o96G-4kh3A:
undetectable
5o96H-4kh3A:
undetectable		 5o96G-4kh3A:
19.17
5o96H-4kh3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		3 / 3 VAL A  33
VAL A  63
GLN A  88
 None
 0.65A 5qgyA-4kh3A:
undetectable		 5qgyA-4kh3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		3 / 3 VAL A  33
VAL A  63
GLN A  88
 None
 0.66A 5qgzA-4kh3A:
undetectable		 5qgzA-4kh3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		3 / 3 VAL A  33
VAL A  63
GLN A  88
 None
 0.66A 5qh0A-4kh3A:
undetectable		 5qh0A-4kh3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		3 / 3 VAL A  33
VAL A  63
GLN A  88
 None
 0.65A 5qh2A-4kh3A:
undetectable		 5qh2A-4kh3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		3 / 3 VAL A  33
VAL A  63
GLN A  88
 None
 0.65A 5qh3A-4kh3A:
undetectable		 5qh3A-4kh3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		3 / 3 GLY A 341
ASN A 321
ARG A 393
 None
 0.54A 5w7bD-4kh3A:
undetectable		 5w7bD-4kh3A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 ILE A 227
VAL A 328
VAL A 255
ALA A 252
LEU A 317
 None
 1.47A 6a7pB-4kh3A:
undetectable		 6a7pB-4kh3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 VAL A 475
LEU A 403
LEU A 449
THR A 401
GLY A 437
 None
 1.12A 6b0lB-4kh3A:
undetectable		 6b0lB-4kh3A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		5 / 12 GLN A 360
GLY A 395
ALA A 392
LEU A 397
ALA A 398
 None
 0.97A 6bq4B-4kh3A:
undetectable		 6bq4B-4kh3A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		4 / 5 THR A 163
THR A  97
GLN A 105
ASP A  79
 None
 1.24A 6ectA-4kh3A:
undetectable		 6ectA-4kh3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 4kh3 ANTIGEN 43
(Escherichia
coli) 		4 / 5 THR A 163
THR A  97
GLN A 105
ASP A  79
 None
 1.32A 6ecxA-4kh3A:
undetectable		 6ecxA-4kh3A:
21.41