SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kh7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		4 / 7 THR A  11
SER A  10
HIS A 110
LEU A 140
 GSH  A 301 ( 4.4A)
GSH  A 301 (-2.5A)
None
None
 1.15A 1ibgL-4kh7A:
undetectable		 1ibgL-4kh7A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		4 / 6 VAL A  13
SER A  10
ARG A   7
LEU A  31
 None
GSH  A 301 (-2.5A)
GSH  A 301 (-3.2A)
None
 1.29A 2f8dA-4kh7A:
undetectable		 2f8dA-4kh7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A  52
PRO A  54
GLU A  67
SER A  68
 GSH  A 301 (-3.3A)
GSH  A 301 (-4.4A)
GSH  A 301 (-2.3A)
GSH  A 301 (-2.7A)
 0.51A 3vlnA-4kh7A:
21.4		 3vlnA-4kh7A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A   4
ILE A   2
LEU A  20
GLU A  21
 None
 0.94A 4w5nA-4kh7A:
undetectable		 4w5nA-4kh7A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		4 / 7 PHE A 159
SER A 155
ALA A  76
LEU A  84
 None
 0.96A 4xk8A-4kh7A:
undetectable		 4xk8A-4kh7A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		3 / 4 ARG A  92
GLY A  95
GLU A  96
 None
 0.64A 4z2dB-4kh7A:
undetectable
4z2dC-4kh7A:
undetectable		 4z2dB-4kh7A:
18.00
4z2dC-4kh7A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		5 / 10 ALA A 165
VAL A  72
LEU A  23
LEU A  84
PHE A 159
 None
 1.21A 4zmeB-4kh7A:
undetectable		 4zmeB-4kh7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		5 / 9 GLN A 151
GLY A 162
GLU A  96
ILE A 166
ALA A 167
 None
 1.35A 5entC-4kh7A:
undetectable		 5entC-4kh7A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		5 / 12 VAL A 170
PHE A 169
LEU A  84
MET A 204
ALA A 198
 None
 1.13A 5fctB-4kh7A:
undetectable		 5fctB-4kh7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		3 / 3 TRP A 180
ILE A 113
GLU A 131
 None
 0.81A 6hcxA-4kh7A:
undetectable		 6hcxA-4kh7A:
17.90