SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 SER A  61
GLU A  62
GLU A  58
 None
 0.65A 1eqbD-4kh8A:
undetectable		 1eqbD-4kh8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 SER A  61
GLU A  62
GLU A  58
 None
 0.65A 1eqbB-4kh8A:
undetectable		 1eqbB-4kh8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 190
ILE A  89
TRP A  65
 None
 1.10A 1m8eB-4kh8A:
undetectable		 1m8eB-4kh8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 190
ILE A  89
TRP A  65
 None
 1.09A 1nodB-4kh8A:
undetectable		 1nodB-4kh8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 190
ILE A  89
TRP A  65
 None
 1.20A 1qomA-4kh8A:
undetectable		 1qomA-4kh8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 5 PHE A 257
PHE A 266
HIS A 292
VAL A 283
 None
 1.09A 2lh6A-4kh8A:
undetectable		 2lh6A-4kh8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 190
ILE A  89
TRP A  65
 None
 1.15A 2nodB-4kh8A:
undetectable		 2nodB-4kh8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 190
ILE A  89
TRP A  65
 None
 1.10A 3e68A-4kh8A:
undetectable		 3e68A-4kh8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 190
ILE A  89
TRP A  65
 None
 1.10A 3e6tB-4kh8A:
undetectable		 3e6tB-4kh8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 190
ILE A  89
TRP A  65
 None
 1.13A 3e7iB-4kh8A:
undetectable		 3e7iB-4kh8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 TYR A  98
TYR A 152
VAL A 139
GLY A 138
HIS A  87
 None
None
None
None
UNL  A 401 ( 4.3A)
 1.38A 3f8wB-4kh8A:
undetectable		 3f8wB-4kh8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 ASN A 323
ASP A 243
ARG A 275
 None
None
SO4  A 407 ( 4.2A)
 0.81A 3k13A-4kh8A:
undetectable		 3k13A-4kh8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 THR A 234
ASN A 232
GLU A 335
 None
 0.67A 3v4tA-4kh8A:
undetectable
3v4tC-4kh8A:
undetectable		 3v4tA-4kh8A:
20.00
3v4tC-4kh8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 5 VAL A 237
TYR A 300
ILE A 295
THR A 274
 None
 1.33A 4ze1A-4kh8A:
undetectable		 4ze1A-4kh8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.66A 5qgnA-4kh8A:
undetectable		 5qgnA-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.65A 5qgyA-4kh8A:
undetectable		 5qgyA-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.67A 5qgzA-4kh8A:
undetectable		 5qgzA-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.65A 5qh0A-4kh8A:
undetectable		 5qh0A-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.65A 5qh2A-4kh8A:
undetectable		 5qh2A-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.67A 5qh3A-4kh8A:
undetectable		 5qh3A-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.67A 5qh5A-4kh8A:
undetectable		 5qh5A-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.67A 5qh7A-4kh8A:
undetectable		 5qh7A-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 168
VAL A  70
GLN A  83
 None
 0.68A 5qhhA-4kh8A:
undetectable		 5qhhA-4kh8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 5 TYR A  98
VAL A 166
PHE A 101
GLY A 110
 None
 1.35A 6hd4A-4kh8A:
undetectable		 6hd4A-4kh8A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4kh8 HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 5 TYR A 264
VAL A 330
PHE A 267
GLY A 276
 None
 1.33A 6hd4A-4kh8A:
undetectable		 6hd4A-4kh8A:
17.41