SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4kha SPT16M-HISTONE H2B
1.1 CHIMERA
(Xenopus
laevis;
Chaetomium
thermophilum) 		3 / 3 VAL A 873
TRP A 857
TRP A 937
 None
 1.37A 1c4dA-4khaA:
undetectable
1c4dB-4khaA:
undetectable		 1c4dA-4khaA:
2.46
1c4dB-4khaA:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4kha SPT16M-HISTONE H2B
1.1 CHIMERA
(Chaetomium
thermophilum;
Xenopus
laevis) 		4 / 7 LEU A 940
GLU A 910
LEU A 860
MET A 921
 None
 1.24A 2w8yA-4khaA:
undetectable		 2w8yA-4khaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4kha SPT16M-HISTONE H2B
1.1 CHIMERA
(Chaetomium
thermophilum;
Xenopus
laevis) 		5 / 9 ILE A 889
LEU A 901
PHE A 821
ILE A 850
ILE A 886
 None
 1.20A 3tq8A-4khaA:
undetectable		 3tq8A-4khaA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4kha SPT16M-HISTONE H2B
1.1 CHIMERA
(Chaetomium
thermophilum;
Xenopus
laevis) 		4 / 7 ILE A 832
ILE A 850
LEU A 901
VAL A 897
 None
 0.72A 3ua5B-4khaA:
undetectable		 3ua5B-4khaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kha SPT16M-HISTONE H2B
1.1 CHIMERA
(Xenopus
laevis;
Chaetomium
thermophilum) 		3 / 3 THR A 851
VAL A 849
GLU A 837
 None
 0.77A 3v4tA-4khaA:
undetectable
3v4tD-4khaA:
undetectable		 3v4tA-4khaA:
22.08
3v4tD-4khaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4kha SPT16M-HISTONE H2B
1.1 CHIMERA
(Chaetomium
thermophilum;
Xenopus
laevis) 		4 / 7 GLU A 892
SER A 893
VAL A 891
ARG A 862
 None
 1.26A 6av6C-4khaA:
0.5
6av6D-4khaA:
undetectable		 6av6C-4khaA:
10.98
6av6D-4khaA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kha SPT16M-HISTONE H2B
1.1 CHIMERA
(Xenopus
laevis;
Chaetomium
thermophilum) 		4 / 5 ILE A 816
LEU A 819
THR A 851
LEU A 852
 None
 0.78A 6nmpN-4khaA:
undetectable
6nmpW-4khaA:
undetectable		 6nmpN-4khaA:
20.96
6nmpW-4khaA:
6.83