SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4kho UNCHARACTERIZED
PROTEIN SPT16M
(Chaetomium
thermophilum) 		5 / 11 LEU A 734
HIS A 731
LEU A 679
VAL A 709
ILE A 675
 None
 1.39A 1ee2A-4khoA:
undetectable		 1ee2A-4khoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4kho UNCHARACTERIZED
PROTEIN SPT16M
(Chaetomium
thermophilum) 		5 / 11 LEU A 734
HIS A 731
LEU A 679
VAL A 709
ILE A 675
 None
 1.41A 1ee2B-4khoA:
undetectable		 1ee2B-4khoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4kho UNCHARACTERIZED
PROTEIN SPT16M
(Chaetomium
thermophilum) 		4 / 7 ILE A 714
HIS A 733
LYS A 746
ILE A 738
 None
 1.05A 3eteD-4khoA:
undetectable
3eteF-4khoA:
undetectable		 3eteD-4khoA:
22.98
3eteF-4khoA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4kho UNCHARACTERIZED
PROTEIN SPT16M
(Chaetomium
thermophilum) 		3 / 3 HIS A 733
HIS A 731
ILE A 842
 None
 0.86A 3u52A-4khoA:
undetectable
3u52C-4khoA:
undetectable		 3u52A-4khoA:
18.93
3u52C-4khoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4kho UNCHARACTERIZED
PROTEIN SPT16M
(Chaetomium
thermophilum) 		4 / 7 ILE A 834
ILE A 852
LEU A 903
VAL A 899
 None
 0.78A 3ua5B-4khoA:
undetectable		 3ua5B-4khoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kho UNCHARACTERIZED
PROTEIN SPT16M
(Chaetomium
thermophilum) 		3 / 3 THR A 853
VAL A 851
GLU A 839
 None
 0.75A 3v4tA-4khoA:
undetectable
3v4tD-4khoA:
undetectable		 3v4tA-4khoA:
21.13
3v4tD-4khoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4kho UNCHARACTERIZED
PROTEIN SPT16M
(Chaetomium
thermophilum) 		4 / 7 ALA A 860
PRO A 909
LEU A 862
LEU A 874
 None
 1.02A 4iomA-4khoA:
undetectable		 4iomA-4khoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kho UNCHARACTERIZED
PROTEIN SPT16M
(Chaetomium
thermophilum) 		4 / 5 ILE A 818
LEU A 821
THR A 853
LEU A 854
 None
 0.86A 6nmpN-4khoA:
undetectable
6nmpW-4khoA:
undetectable		 6nmpN-4khoA:
20.19
6nmpW-4khoA:
9.57