SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ki9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12
(Homo
sapiens) 		5 / 12 ILE A 125
ALA A 152
GLY A  37
GLY A 118
LEU A 112
 None
None
None
PO4  A 201 (-3.8A)
None
 1.09A 1rjdA-4ki9A:
undetectable		 1rjdA-4ki9A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12
(Homo
sapiens) 		5 / 12 ILE A 125
ALA A 152
GLY A  37
GLY A 118
LEU A 112
 None
None
None
PO4  A 201 (-3.8A)
None
 1.09A 1rjdB-4ki9A:
undetectable		 1rjdB-4ki9A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12
(Homo
sapiens) 		5 / 9 ALA A 124
SER A 122
PHE A  36
GLY A 118
ALA A 152
 None
PO4  A 201 ( 4.3A)
None
PO4  A 201 (-3.8A)
None
 1.07A 2vh3A-4ki9A:
undetectable		 2vh3A-4ki9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12
(Homo
sapiens) 		4 / 5 LEU A  28
LYS A 144
GLN A 146
LEU A 148
 None
 0.90A 3h5gA-4ki9A:
undetectable
3h5gB-4ki9A:
undetectable		 3h5gA-4ki9A:
11.66
3h5gB-4ki9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12
(Homo
sapiens) 		5 / 12 VAL A  30
LEU A  57
ILE A 101
LEU A  34
LEU A  90
 None
 1.16A 5ienA-4ki9A:
undetectable		 5ienA-4ki9A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12
(Homo
sapiens) 		4 / 6 LEU A 145
TYR A 142
VAL A 172
PHE A  36
 None
 1.02A 6hd4B-4ki9A:
undetectable		 6hd4B-4ki9A:
21.09