SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4kit PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 ALA C2227
LEU C2188
PRO C2232
SER C2233
THR C2226
 None
 1.16A 3nrrA-4kitC:
undetectable		 3nrrA-4kitC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4kit PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 ALA C2227
LEU C2188
PRO C2232
SER C2233
THR C2226
 None
 1.20A 3nrrB-4kitC:
undetectable		 3nrrB-4kitC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4kit PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 9 ALA C2125
GLY C2176
ILE C2212
THR C2195
VAL C2157
 None
 1.15A 4nptA-4kitC:
undetectable		 4nptA-4kitC:
16.61