SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4kiw 3-DEHYDROQUINATE
DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  13
SER A 115
LEU A 117
GLY A  77
 KIW  A 500 ( 4.3A)
None
None
KIW  A 500 (-3.6A)
 1.14A 1a4lB-4kiwA:
undetectable		 1a4lB-4kiwA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4kiw 3-DEHYDROQUINATE
DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 137
LEU A  45
LYS A   3
HIS A 143
 None
 0.99A 2wekA-4kiwA:
undetectable		 2wekA-4kiwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4kiw 3-DEHYDROQUINATE
DEHYDRATASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  99
HIS A 101
THR A  80
 None
KIW  A 500 (-4.2A)
None
 0.85A 3hkuA-4kiwA:
undetectable		 3hkuA-4kiwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4kiw 3-DEHYDROQUINATE
DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 4 PRO A  21
TYR A  24
GLY A  17
THR A  28
 None
KIW  A 500 (-4.2A)
None
None
 1.49A 3ib0A-4kiwA:
undetectable		 3ib0A-4kiwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4kiw 3-DEHYDROQUINATE
DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 9 TRP A  61
ILE A   8
ALA A  76
THR A  80
ALA A  85
 None
 1.31A 4oqrA-4kiwA:
undetectable		 4oqrA-4kiwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4kiw 3-DEHYDROQUINATE
DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 7 HIS A  81
HIS A 101
LEU A  74
SER A 118
 KIW  A 500 (-3.6A)
KIW  A 500 (-4.2A)
None
None
 1.06A 5m8rA-4kiwA:
undetectable		 5m8rA-4kiwA:
16.79