SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kjd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 6 LEU A 253
GLU A 216
ASP A 285
PRO A 286
 None
MG  A 502 (-2.6A)
MG  A 502 (-3.2A)
None
 1.23A 1ditH-4kjdA:
undetectable
1ditP-4kjdA:
undetectable		 1ditH-4kjdA:
17.74
1ditP-4kjdA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 THR A  48
THR A  50
PRO A  47
 None
 0.83A 1dscC-4kjdA:
undetectable		 1dscC-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 6 VAL A 247
GLY A 267
LEU A 200
GLU A 290
 None
 1.04A 1fduD-4kjdA:
undetectable		 1fduD-4kjdA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 4 GLY A 318
ASP A 316
GLY A  41
THR A 147
 None
 1.06A 1hxbB-4kjdA:
undetectable		 1hxbB-4kjdA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 10 ASP A 316
GLY A 434
GLY A 433
PRO A  47
THR A  48
 None
 0.69A 1k6cA-4kjdA:
undetectable		 1k6cA-4kjdA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 THR A  48
THR A  50
PRO A  47
 None
 0.87A 1qfiB-4kjdA:
undetectable		 1qfiB-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 THR A  48
THR A  50
PRO A  47
 None
 0.86A 1unjL-4kjdA:
undetectable		 1unjL-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 THR A  48
THR A  50
PRO A  47
 None
 0.83A 1unjW-4kjdA:
undetectable		 1unjW-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 THR A  48
THR A  50
PRO A  47
 None
 0.85A 1unjX-4kjdA:
undetectable		 1unjX-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 THR A  50
PRO A  47
THR A  48
 None
 0.86A 1unmE-4kjdA:
undetectable		 1unmE-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 THR A  48
THR A  50
PRO A  47
 None
 0.82A 1unmE-4kjdA:
undetectable		 1unmE-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 THR A  48
THR A  50
PRO A  47
 None
 0.84A 1unmF-4kjdA:
undetectable		 1unmF-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 7 LEU A 190
MET A 133
VAL A 132
SER A 131
 None
 0.88A 1wrlA-4kjdA:
undetectable
1wrlB-4kjdA:
undetectable		 1wrlA-4kjdA:
10.81
1wrlB-4kjdA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 PHE A  39
PRO A 156
ALA A 157
ALA A 337
LEU A 200
 None
 1.29A 2x2nB-4kjdA:
undetectable		 2x2nB-4kjdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 6 HIS A 153
ALA A  93
ALA A  96
PHE A 309
 SEP  A  92 ( 4.9A)
SEP  A  92 ( 3.7A)
SEP  A  92 ( 3.3A)
None
 1.04A 2xfhA-4kjdA:
undetectable		 2xfhA-4kjdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 LEU A 328
LEU A  38
ARG A 442
ILE A 458
VAL A 437
 None
 0.90A 2ygnA-4kjdA:
undetectable		 2ygnA-4kjdA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 8 ASP A 316
GLY A 433
PRO A  47
THR A  48
 None
 0.60A 3el9A-4kjdA:
undetectable		 3el9A-4kjdA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 4 GLY A 318
ASP A 316
GLY A  41
THR A 147
 None
 1.04A 3k4vC-4kjdA:
undetectable		 3k4vC-4kjdA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 ASP A 173
ILE A 186
ASN A 165
ARG A 117
ILE A 110
 None
 1.22A 3ohtA-4kjdA:
undetectable
3ohtB-4kjdA:
undetectable		 3ohtA-4kjdA:
20.70
3ohtB-4kjdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 8 GLY A 203
THR A 272
GLN A 152
GLU A 273
 None
 0.91A 3rglA-4kjdA:
undetectable		 3rglA-4kjdA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 5 PHE A 334
ILE A 354
GLY A 312
ILE A 338
LEU A  40
 None
 1.50A 5dzkB-4kjdA:
undetectable
5dzkI-4kjdA:
undetectable
5dzkW-4kjdA:
undetectable		 5dzkB-4kjdA:
18.31
5dzkI-4kjdA:
17.12
5dzkW-4kjdA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 LEU A  40
ASP A 357
THR A  95
HIS A 153
PHE A 309
 None
SEP  A  92 ( 3.8A)
SEP  A  92 ( 4.2A)
SEP  A  92 ( 4.9A)
None
 1.48A 5m5kB-4kjdA:
undetectable		 5m5kB-4kjdA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 ALA A 261
ALA A 139
ALA A 136
LEU A 299
THR A 244
 None
 1.26A 5tl8A-4kjdA:
undetectable		 5tl8A-4kjdA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 PHE A 309
ALA A 337
PHE A 334
GLY A 312
GLY A  41
 None
 1.20A 5ul4A-4kjdA:
undetectable		 5ul4A-4kjdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 GLY A  41
VAL A 461
LEU A 351
VAL A 449
ILE A 439
 None
 1.00A 5vopA-4kjdA:
undetectable		 5vopA-4kjdA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 8 PHE A  39
ILE A 354
PHE A 334
PRO A  68
 None
 1.12A 5x23A-4kjdA:
undetectable		 5x23A-4kjdA:
20.69