SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kjv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 4kjv E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		4 / 7 GLU A 183
TRP A 217
PHE A 229
ARG A 166
 None
 1.39A 1b2iA-4kjvA:
undetectable		 1b2iA-4kjvA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4kjv E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 PRO A 174
GLY A 195
TYR A 191
 None
 0.66A 2vouA-4kjvA:
undetectable		 2vouA-4kjvA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4kjv E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 PRO A 174
GLY A 195
TYR A 191
 None
 0.64A 2vouB-4kjvA:
undetectable		 2vouB-4kjvA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4kjv E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 PRO A 174
GLY A 195
TYR A 191
 None
 0.63A 2vouC-4kjvA:
undetectable		 2vouC-4kjvA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4kjv E3 UBIQUITIN-PROTEIN
LIGASE XIAP
(Homo
sapiens) 		3 / 3 LEU A 189
ARG A 222
ASN A 226
 None
1RK  A 502 (-4.2A)
None
 0.67A 3qxvD-4kjvA:
undetectable		 3qxvD-4kjvA:
18.11