SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kjy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 4kjy HIGH-AFFINITY SIRPA
VARIANT FD6
(Homo
sapiens) 		5 / 12 LEU B 111
HIS B  24
SER B  77
ILE B  76
ILE B  81
 None
 1.29A 1ot7B-4kjyB:
undetectable		 1ot7B-4kjyB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4kjy HIGH-AFFINITY SIRPA
VARIANT FD6
(Homo
sapiens) 		5 / 10 ILE B  49
ASP B  85
LEU B 111
ILE B  22
ILE B  76
 None
 1.29A 1rb3A-4kjyB:
undetectable		 1rb3A-4kjyB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4kjy HIGH-AFFINITY SIRPA
VARIANT FD6
(Homo
sapiens) 		5 / 12 GLN B   8
GLY B  41
ILE B  78
LEU B 111
GLY B  87
 None
 0.89A 1uakA-4kjyB:
undetectable		 1uakA-4kjyB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4kjy LEUKOCYTE SURFACE
ANTIGEN CD47
(Homo
sapiens) 		4 / 7 PHE A  24
ILE A  47
THR A 107
THR A  18
 None
None
SO4  A 201 (-3.9A)
None
 0.97A 3nxuA-4kjyA:
undetectable		 3nxuA-4kjyA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4kjy HIGH-AFFINITY SIRPA
VARIANT FD6
(Homo
sapiens) 		5 / 12 GLN B   8
GLY B  41
ILE B  78
LEU B 111
GLY B  87
 None
 0.91A 5wyqB-4kjyB:
undetectable		 5wyqB-4kjyB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 4kjy LEUKOCYTE SURFACE
ANTIGEN CD47
HIGH-AFFINITY SIRPA
VARIANT FD6
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B  36
LEU B  48
PHE B  39
ASP B 100
LYS A  39
 None
 1.32A 6dwnB-4kjyB:
undetectable		 6dwnB-4kjyB:
18.52