SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 PHE A 113
VAL A 115
ILE A 230
ILE A 149
LEU A  93
 None
 1.14A 1fm4A-4kjzA:
undetectable		 1fm4A-4kjzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.96A 1hsgB-4kjzA:
undetectable		 1hsgB-4kjzA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 PHE A 177
ALA A 170
ALA A 168
LEU A 226
GLY A 172
 None
 1.16A 1qabF-4kjzA:
undetectable		 1qabF-4kjzA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.97A 1sdtB-4kjzA:
undetectable		 1sdtB-4kjzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 5 ASP A 416
GLY A 410
PRO A 435
VAL A 438
 None
 0.83A 2aojA-4kjzA:
undetectable		 2aojA-4kjzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.85A 2avoB-4kjzA:
undetectable		 2avoB-4kjzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.94A 2q63B-4kjzA:
undetectable		 2q63B-4kjzA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 1.01A 2qhcB-4kjzA:
undetectable		 2qhcB-4kjzA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 11 LEU A 231
LEU A  93
ILE A 215
VAL A 148
ILE A 146
 None
 1.22A 2uxoB-4kjzA:
undetectable		 2uxoB-4kjzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.85A 3el1B-4kjzA:
undetectable		 3el1B-4kjzA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 10 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.88A 3em3A-4kjzA:
undetectable		 3em3A-4kjzA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		3 / 3 PHE A 430
TYR A 456
LEU A 449
 None
 0.75A 3keeB-4kjzA:
undetectable		 3keeB-4kjzA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.94A 3ndtD-4kjzA:
undetectable		 3ndtD-4kjzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.92A 3oxcA-4kjzA:
undetectable		 3oxcA-4kjzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 10 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.88A 3oy4B-4kjzA:
undetectable		 3oy4B-4kjzA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 7 PHE A 113
ASP A  91
ILE A  78
VAL A  76
 None
 0.77A 3p6hA-4kjzA:
undetectable		 3p6hA-4kjzA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.97A 3pwrB-4kjzA:
undetectable		 3pwrB-4kjzA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.96A 3tkgD-4kjzA:
undetectable		 3tkgD-4kjzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 8 ASP A 238
VAL A 122
GLN A 119
GLY A 120
 None
 0.74A 4acbC-4kjzA:
18.4		 4acbC-4kjzA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 8 ASP A 380
GLU A 237
ASP A 209
GLU A 204
 None
 1.08A 4feuF-4kjzA:
undetectable		 4feuF-4kjzA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 8 ASP A 380
GLU A 237
ASP A 209
GLU A 204
 None
 1.01A 4gkhB-4kjzA:
undetectable		 4gkhB-4kjzA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 8 ASP A 380
GLU A 237
ASP A 209
GLU A 204
 None
 1.06A 4gkiC-4kjzA:
undetectable		 4gkiC-4kjzA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 9 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.88A 5kr0B-4kjzA:
undetectable		 5kr0B-4kjzA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 11 GLY A 383
GLY A 200
LEU A 377
THR A 381
ALA A 379
 None
 0.96A 5o96G-4kjzA:
5.5		 5o96G-4kjzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 10 GLY A 383
GLY A 200
LEU A 377
THR A 381
ALA A 379
 None
 0.94A 5o96G-4kjzA:
5.6
5o96H-4kjzA:
5.8		 5o96G-4kjzA:
21.79
5o96H-4kjzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 7 ILE A 391
LEU A 377
THR A 381
ARG A 453
 None
 1.03A 5vc0A-4kjzA:
undetectable		 5vc0A-4kjzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kjz TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 10 GLY A 383
GLY A 200
LEU A 377
THR A 381
ALA A 379
 None
 1.08A 5vm8B-4kjzA:
5.3		 5vm8B-4kjzA:
19.26