SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 6 ALA A  74
SER A  34
LEU A  71
TRP A  72
 None
 1.07A 1gahA-4kk1A:
undetectable		 1gahA-4kk1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 276
PHE A 354
HIS A 392
LEU A 388
 None
 1.06A 1x8vA-4kk1A:
undetectable		 1x8vA-4kk1A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 150
SER A 153
TYR A 151
LEU A 175
 None
 1.27A 1xz1A-4kk1A:
undetectable		 1xz1A-4kk1A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 150
SER A 153
TYR A 151
LEU A 175
 None
 1.28A 1xz3A-4kk1A:
undetectable		 1xz3A-4kk1A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 8 ASN A 353
LEU A 363
ALA A 365
SER A 366
 None
 0.95A 3kp6A-4kk1A:
undetectable		 3kp6A-4kk1A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		6 / 12 PRO A 226
ILE A 254
LEU A 233
ALA A 238
ILE A 215
LEU A 208
 None
 1.26A 3vrmA-4kk1A:
undetectable		 3vrmA-4kk1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU A 130
ARG A 136
GLN A  36
 None
 0.92A 4rtbA-4kk1A:
undetectable		 4rtbA-4kk1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 8 HIS A 301
ASP A 241
ARG A 204
PRO A 244
 None
 1.22A 4uhxA-4kk1A:
undetectable		 4uhxA-4kk1A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 8 HIS A 301
ASP A 241
ARG A 204
PRO A 244
 None
 1.22A 4uhxA-4kk1A:
undetectable		 4uhxA-4kk1A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 4 VAL A  75
ILE A  57
ASN A  12
VAL A   7
 None
 1.18A 5ajqA-4kk1A:
undetectable		 5ajqA-4kk1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 234
LEU A 190
SER A 191
ILE A 144
 None
 0.96A 5jw1A-4kk1A:
undetectable		 5jw1A-4kk1A:
20.66