SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 178
ILE A 174
ILE A 335
ALA A 186
THR A 360
 None
 1.23A 1jtxA-4kk7A:
undetectable		 1jtxA-4kk7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 445
VAL A 395
TYR A 418
TYR A 410
 None
 0.99A 1lweA-4kk7A:
undetectable		 1lweA-4kk7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 441
ALA A 235
GLN A 349
PRO A 180
LEU A 172
 None
 1.23A 1u70A-4kk7A:
undetectable		 1u70A-4kk7A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 262
PHE A 268
ARG A 322
 None
 0.83A 1xdkF-4kk7A:
undetectable		 1xdkF-4kk7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 455
PRO A 131
GLY A 132
ALA A 101
LEU A  75
 None
 1.06A 2plwA-4kk7A:
undetectable		 2plwA-4kk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 258
PRO A 259
LEU A 262
 None
 0.50A 2qd5B-4kk7A:
undetectable		 2qd5B-4kk7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 291
THR A 292
ALA A 295
PRO A 332
 None
 0.62A 2ql8A-4kk7A:
undetectable
2ql8B-4kk7A:
undetectable		 2ql8A-4kk7A:
18.91
2ql8B-4kk7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 361
HIS A 204
LEU A 181
ILE A 228
 None
 0.98A 3avpA-4kk7A:
undetectable		 3avpA-4kk7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 296
LEU A 244
VAL A 289
ILE A 247
LEU A 282
 None
 1.21A 3fl9F-4kk7A:
undetectable		 3fl9F-4kk7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 451
THR A 137
THR A  99
LEU A 431
GLY A 430
 None
 1.48A 3h9uC-4kk7A:
undetectable		 3h9uC-4kk7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 451
THR A 137
THR A  99
LEU A 431
GLY A 430
 None
 1.49A 3h9uD-4kk7A:
undetectable		 3h9uD-4kk7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 179
SER A 363
GLY A 364
ASP A 175
 NI  A 502 (-2.4A)
None
None
TRS  A 505 (-2.8A)
 1.31A 3w9tB-4kk7A:
undetectable		 3w9tB-4kk7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 179
SER A 363
GLY A 364
ASP A 175
 NI  A 502 (-2.4A)
None
None
TRS  A 505 (-2.8A)
 1.31A 3w9tC-4kk7A:
undetectable		 3w9tC-4kk7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 179
SER A 363
GLY A 364
ASP A 175
 NI  A 502 (-2.4A)
None
None
TRS  A 505 (-2.8A)
 1.31A 3w9tD-4kk7A:
undetectable		 3w9tD-4kk7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 449
ILE A 130
VAL A 104
THR A 425
ASN A 422
 None
 1.43A 4xe0A-4kk7A:
undetectable		 4xe0A-4kk7A:
17.83