SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		3 / 3 ALA A 416
VAL A 419
TRP A 420
 None
 1.01A 1c4dA-4kkdA:
undetectable
1c4dB-4kkdA:
undetectable		 1c4dA-4kkdA:
2.96
1c4dB-4kkdA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 HIS A 497
VAL A 684
TRP A 686
GLY A 687
GLY A 699
 None
 0.54A 1etrH-4kkdA:
29.5		 1etrH-4kkdA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 8 VAL A 516
VAL A 469
LEU A 499
TRP A 480
 None
 0.61A 2gehA-4kkdA:
undetectable		 2gehA-4kkdA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		6 / 12 TYR A 550
VAL A 684
TRP A 686
GLY A 687
GLY A 699
TYR A 701
 None
 0.66A 2p16A-4kkdA:
28.3		 2p16A-4kkdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		6 / 12 TYR A 550
VAL A 684
GLY A 687
GLY A 688
GLY A 699
TYR A 701
 None
 1.02A 2w26A-4kkdA:
28.3		 2w26A-4kkdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		6 / 12 TYR A 550
VAL A 684
TRP A 686
GLY A 687
GLY A 699
TYR A 701
 None
 0.61A 2w26A-4kkdA:
28.3		 2w26A-4kkdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 LEU A 493
LEU A 556
GLN A 714
VAL A 708
THR A 702
 None
 1.40A 2yloA-4kkdA:
undetectable		 2yloA-4kkdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 VAL A 516
ILE A 467
VAL A 469
LEU A 499
TRP A 480
 None
 0.90A 3fw3A-4kkdA:
undetectable		 3fw3A-4kkdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 VAL A 516
ILE A 467
VAL A 469
LEU A 499
TRP A 480
 None
 0.85A 3fw3B-4kkdA:
undetectable		 3fw3B-4kkdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 10 ALA A 555
THR A 494
ILE A 467
VAL A 516
VAL A 518
 None
 1.09A 3me6A-4kkdA:
undetectable		 3me6A-4kkdA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 6 VAL A 684
TRP A 686
GLY A 687
GLY A 699
 None
 0.55A 3rxfA-4kkdA:
8.9		 3rxfA-4kkdA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 11 TRP A 593
GLY A 482
GLU A 666
SER A 664
GLY A 592
 None
 1.37A 4ey7A-4kkdA:
undetectable		 4ey7A-4kkdA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 11 TRP A 593
GLY A 482
GLU A 666
SER A 664
GLY A 592
 None
 1.39A 4ey7B-4kkdA:
undetectable		 4ey7B-4kkdA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 7 LEU A 617
PRO A 439
SER A 440
VAL A 572
 None
 1.07A 4klrA-4kkdA:
undetectable		 4klrA-4kkdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 LEU A 574
LEU A 493
ILE A 492
LEU A 556
PRO A 434
 None
 0.89A 4odrA-4kkdA:
undetectable
4odrB-4kkdA:
undetectable		 4odrA-4kkdA:
11.78
4odrB-4kkdA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 11 PRO A 434
LEU A 574
LEU A 493
ILE A 492
LEU A 556
 None
 1.02A 4odrA-4kkdA:
undetectable
4odrB-4kkdA:
undetectable		 4odrA-4kkdA:
11.78
4odrB-4kkdA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 HIS A 497
VAL A 684
TRP A 686
GLY A 687
GLY A 699
 None
 0.49A 4rn6B-4kkdA:
31.0		 4rn6B-4kkdA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 7 VAL A 711
TRP A 491
LEU A 487
SER A 488
 None
 1.10A 4zphA-4kkdA:
undetectable
4zphB-4kkdA:
undetectable		 4zphA-4kkdA:
23.03
4zphB-4kkdA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 4 LEU A 466
LEU A 617
GLY A 592
GLU A 666
 None
 1.24A 5hhjA-4kkdA:
undetectable		 5hhjA-4kkdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 8 VAL A 516
VAL A 469
LEU A 499
TRP A 480
 None
 0.76A 5tt3F-4kkdA:
undetectable		 5tt3F-4kkdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 5 SER A 328
VAL A 327
LYS A 311
PRO A 314
 None
 0.83A 6fi4A-4kkdA:
undetectable
6fi4B-4kkdA:
undetectable		 6fi4A-4kkdA:
19.72
6fi4B-4kkdA:
2.76