SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4kkj TRANSCOBALAMIN-1
(Homo
sapiens) 		4 / 5 THR A 221
GLU A 252
THR A 251
LEU A 271
 None
 1.30A 1d4fC-4kkjA:
undetectable		 1d4fC-4kkjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 4kkj TRANSCOBALAMIN-1
(Homo
sapiens) 		4 / 6 PHE A 258
LEU A 250
VAL A   5
VAL A 267
 None
 0.96A 1e7aB-4kkjA:
undetectable		 1e7aB-4kkjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4kkj TRANSCOBALAMIN-1
(Homo
sapiens) 		5 / 10 LEU A 126
LEU A 129
ALA A 130
LEU A  36
LEU A  72
 None
 1.29A 1gwrA-4kkjA:
undetectable		 1gwrA-4kkjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4kkj TRANSCOBALAMIN-1
(Homo
sapiens) 		4 / 7 GLY A 165
ALA A 166
MET A 167
LEU A 170
 None
 0.33A 2wekB-4kkjA:
undetectable		 2wekB-4kkjA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4kkj TRANSCOBALAMIN-1
(Homo
sapiens) 		4 / 7 MET A 339
VAL A 405
ILE A 363
TYR A 315
 None
None
CBY  A 508 (-4.0A)
None
 1.05A 2yfbA-4kkjA:
undetectable		 2yfbA-4kkjA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4kkj TRANSCOBALAMIN-1
(Homo
sapiens) 		4 / 6 GLY A 165
ASP A 127
ASP A 163
ASN A 120
 None
None
CBY  A 508 (-2.7A)
CBY  A 508 (-3.3A)
 1.01A 3vywC-4kkjA:
undetectable		 3vywC-4kkjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4kkj TRANSCOBALAMIN-1
(Homo
sapiens) 		3 / 3 LEU A  89
ASP A  92
TYR A  93
 None
 0.61A 4qc6B-4kkjA:
undetectable		 4qc6B-4kkjA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4kkj TRANSCOBALAMIN-1
(Homo
sapiens) 		5 / 12 ILE A   2
ASP A 278
LEU A 277
LEU A 246
THR A 245
 None
 1.18A 5tiwB-4kkjA:
undetectable		 5tiwB-4kkjA:
18.24