SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.07A 1cqeB-4kl0A:
undetectable		 1cqeB-4kl0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 11 TYR A 320
GLU A 197
GLY A 198
LEU A 201
VAL A 125
 None
 1.28A 1i9jH-4kl0A:
undetectable
1i9jL-4kl0A:
undetectable		 1i9jH-4kl0A:
19.79
1i9jL-4kl0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.03A 2aylA-4kl0A:
undetectable		 2aylA-4kl0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.05A 2aylB-4kl0A:
undetectable		 2aylB-4kl0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		6 / 12 PHE A 319
ALA A 324
GLY A 327
GLY A 163
LEU A 201
LEU A 160
 None
 1.38A 2hw2A-4kl0A:
undetectable		 2hw2A-4kl0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		3 / 3 LEU A 401
PRO A 400
LEU A 404
 None
 0.57A 2po7B-4kl0A:
2.8		 2po7B-4kl0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 10 TYR A 311
ALA A 314
ASN A 396
ALA A 310
ALA A 313
 None
 1.34A 2r2vC-4kl0A:
undetectable
2r2vF-4kl0A:
undetectable
2r2vG-4kl0A:
undetectable		 2r2vC-4kl0A:
6.90
2r2vF-4kl0A:
6.90
2r2vG-4kl0A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		4 / 6 LEU A  89
THR A  90
ARG A 101
LEU A 444
 None
 1.10A 2wm3A-4kl0A:
6.8		 2wm3A-4kl0A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 THR A 236
GLY A 234
ASN A 280
ASN A 281
GLY A 212
 None
None
CA  A 501 ( 4.5A)
None
None
 1.09A 3eeyA-4kl0A:
4.0		 3eeyA-4kl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 THR A 236
GLY A 234
ASN A 280
ASN A 281
GLY A 212
 None
None
CA  A 501 ( 4.5A)
None
None
 1.10A 3eeyB-4kl0A:
4.0		 3eeyB-4kl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 THR A 236
GLY A 234
ASN A 280
ASN A 281
GLY A 212
 None
None
CA  A 501 ( 4.5A)
None
None
 1.11A 3eeyH-4kl0A:
4.3		 3eeyH-4kl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 THR A 236
GLY A 234
ASN A 280
ASN A 281
GLY A 212
 None
None
CA  A 501 ( 4.5A)
None
None
 1.10A 3eeyI-4kl0A:
4.3		 3eeyI-4kl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.06A 3ln1A-4kl0A:
undetectable		 3ln1A-4kl0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.07A 3ln1B-4kl0A:
undetectable		 3ln1B-4kl0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.06A 3ln1C-4kl0A:
undetectable		 3ln1C-4kl0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.07A 3ln1D-4kl0A:
undetectable		 3ln1D-4kl0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 175
LEU A 113
THR A 115
TYR A 127
VAL A 164
 None
 1.49A 3mbhB-4kl0A:
5.7		 3mbhB-4kl0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.05A 3n8wA-4kl0A:
undetectable		 3n8wA-4kl0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 ALA A 452
LEU A 454
LEU A 334
ALA A 450
LEU A 395
 None
 1.15A 3r9cA-4kl0A:
undetectable		 3r9cA-4kl0A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 THR A 126
ILE A 129
TYR A 320
PHE A 319
TYR A 333
 None
 1.14A 3rzeA-4kl0A:
undetectable		 3rzeA-4kl0A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 9 THR A 410
THR A 111
LEU A 404
LEU A 403
THR A 257
 None
 1.41A 4c9kA-4kl0A:
undetectable		 4c9kA-4kl0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		4 / 6 TYR A 127
LEU A 139
VAL A 253
ALA A 254
 None
 1.16A 4nkvC-4kl0A:
undetectable		 4nkvC-4kl0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 GLY A 432
ALA A 309
ASN A 280
ASN A 281
ILE A 304
 None
None
CA  A 501 ( 4.5A)
None
None
 1.29A 4pb1A-4kl0A:
undetectable		 4pb1A-4kl0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.08A 5ikrB-4kl0A:
undetectable		 5ikrB-4kl0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.06A 5jvzA-4kl0A:
undetectable		 5jvzA-4kl0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 12 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.05A 5jvzB-4kl0A:
undetectable		 5jvzB-4kl0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		5 / 10 LEU A 401
GLY A 432
LEU A 414
ARG A 438
ALA A 442
 None
 1.16A 5o96E-4kl0A:
4.0
5o96F-4kl0A:
3.9		 5o96E-4kl0A:
23.62
5o96F-4kl0A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		3 / 3 GLY A 149
LEU A 148
HIS A 191
 None
 0.52A 5u63A-4kl0A:
2.4		 5u63A-4kl0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		3 / 3 GLY A 149
LEU A 148
HIS A 191
 None
 0.47A 5u63B-4kl0A:
2.2		 5u63B-4kl0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Xanthomonas
oryzae) 		4 / 6 PHE A 165
ARG A 167
LEU A 168
ALA A 130
 None
 0.97A 6b89B-4kl0A:
undetectable		 6b89B-4kl0A:
11.72