SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		4 / 5 ALA A 206
TYR A 208
ALA A 202
TYR A 204
 None
None
None
RET  A 301 (-4.1A)
 1.07A 1xl6A-4klyA:
undetectable
1xl6B-4klyA:
2.8		 1xl6A-4klyA:
23.87
1xl6B-4klyA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		4 / 4 ALA A 206
TYR A 208
ALA A 202
TYR A 204
 None
None
None
RET  A 301 (-4.1A)
 1.09A 2wlkA-4klyA:
undetectable
2wlkB-4klyA:
2.0		 2wlkA-4klyA:
23.87
2wlkB-4klyA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		4 / 8 GLY A 212
GLY A 207
TYR A 224
LEU A 220
 None
 0.73A 4fgzB-4klyA:
undetectable		 4fgzB-4klyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		3 / 3 THR A 177
ASN A 183
SER A 179
 None
 0.74A 4tvtA-4klyA:
undetectable		 4tvtA-4klyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.27A 5ksgB-4klyA:
undetectable		 5ksgB-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.25A 5ksnA-4klyA:
undetectable		 5ksnA-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.26A 5ksnB-4klyA:
undetectable		 5ksnB-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.28A 5kt8B-4klyA:
undetectable		 5kt8B-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 8 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.24A 5sxqA-4klyA:
undetectable		 5sxqA-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 8 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.23A 5sxqB-4klyA:
undetectable		 5sxqB-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.25A 5sxsB-4klyA:
undetectable		 5sxsB-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.27A 5syiB-4klyA:
undetectable		 5syiB-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		4 / 8 GLU A 108
VAL A 107
GLY A  66
THR A  69
 None
 0.88A 5syjA-4klyA:
undetectable		 5syjA-4klyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 12 VAL A 107
PHE A 235
VAL A 242
SER A  61
VAL A  64
 None
 1.27A 6ap6A-4klyA:
undetectable		 6ap6A-4klyA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 12 VAL A 107
PHE A 235
VAL A 242
SER A  61
VAL A  64
 None
 1.29A 6ap6B-4klyA:
undetectable		 6ap6B-4klyA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.28A 6cdqA-4klyA:
0.6		 6cdqA-4klyA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.28A 6cdqB-4klyA:
0.8		 6cdqB-4klyA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		5 / 9 GLU A 108
VAL A 107
GLY A  66
LEU A  67
THR A  69
 None
 1.25A 6cfqB-4klyA:
undetectable		 6cfqB-4klyA:
14.77