SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4klz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4klz GTP-BINDING PROTEIN
RIT1
(Homo
sapiens) 		4 / 7 PHE A 161
ALA A 177
PRO A 159
GLU A 181
 None
 0.96A 1oniA-4klzA:
undetectable
1oniB-4klzA:
undetectable		 1oniA-4klzA:
23.12
1oniB-4klzA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4klz GTP-BINDING PROTEIN
RIT1
(Homo
sapiens) 		4 / 7 PRO A 159
GLU A 181
PHE A 161
ALA A 177
 None
 0.94A 1oniG-4klzA:
undetectable
1oniI-4klzA:
undetectable		 1oniG-4klzA:
23.12
1oniI-4klzA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4klz GTP-BINDING PROTEIN
RIT1
(Homo
sapiens) 		5 / 12 ILE A  42
ASP A 172
ALA A  69
ILE A  97
MET A  26
 None
 1.16A 5igvA-4klzA:
undetectable		 5igvA-4klzA:
21.67