SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4km3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 201
GLY A 198
LEU A 196
MET A 234
VAL A  79
 None
 0.90A 1fduC-4km3A:
undetectable		 1fduC-4km3A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A  91
GLY A  92
THR A 145
PRO A 146
 None
 0.95A 1n4fA-4km3A:
undetectable		 1n4fA-4km3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 8 VAL A 100
HIS A 252
GLU A 232
ASP A 136
 None
 1.17A 1s3zA-4km3A:
undetectable
1s3zB-4km3A:
undetectable		 1s3zA-4km3A:
19.79
1s3zB-4km3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		6 / 12 GLN A 266
GLY A 132
VAL A 100
LEU A 101
GLY A 102
GLY A 103
 None
 1.30A 1uakA-4km3A:
undetectable		 1uakA-4km3A:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A  67
CYH A  72
HIS A  81
TRP A 250
 None
 0.40A 1yvmA-4km3A:
32.5		 1yvmA-4km3A:
35.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 185
GLU A 186
ARG A 194
ILE A 231
GLY A 164
 None
 1.19A 2yjaB-4km3A:
undetectable		 2yjaB-4km3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 9 GLY A 258
LEU A 153
ASN A  76
ASN A 236
ILE A 235
 None
 1.42A 3wdmA-4km3A:
undetectable		 3wdmA-4km3A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 6 TYR A  87
ASP A  77
GLU A 149
LEU A  95
 None
 1.27A 4ax8A-4km3A:
undetectable		 4ax8A-4km3A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		3 / 3 MET A  99
MET A 234
TYR A 141
 None
 1.30A 4p6xI-4km3A:
undetectable		 4p6xI-4km3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A  83
THR A 204
GLU A 264
ASP A 136
 None
 1.39A 4qb9D-4km3A:
undetectable		 4qb9D-4km3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.43A 4qvlV-4km3A:
undetectable
4qvlb-4km3A:
undetectable		 4qvlV-4km3A:
21.85
4qvlb-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.43A 4qvlH-4km3A:
undetectable
4qvlN-4km3A:
undetectable		 4qvlH-4km3A:
21.85
4qvlN-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.42A 4qvmV-4km3A:
undetectable
4qvmb-4km3A:
undetectable		 4qvmV-4km3A:
21.85
4qvmb-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.42A 4qvmH-4km3A:
undetectable
4qvmN-4km3A:
undetectable		 4qvmH-4km3A:
21.85
4qvmN-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.45A 4qvpV-4km3A:
undetectable
4qvpb-4km3A:
undetectable		 4qvpV-4km3A:
21.85
4qvpb-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.46A 4qvqH-4km3A:
undetectable
4qvqN-4km3A:
undetectable		 4qvqH-4km3A:
21.85
4qvqN-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 10 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.42A 4qvvV-4km3A:
0.0
4qvvb-4km3A:
undetectable		 4qvvV-4km3A:
21.85
4qvvb-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 10 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.43A 4qvvH-4km3A:
undetectable
4qvvN-4km3A:
0.0		 4qvvH-4km3A:
21.85
4qvvN-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.45A 4qvwV-4km3A:
undetectable
4qvwb-4km3A:
undetectable		 4qvwV-4km3A:
21.85
4qvwb-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.45A 4qvwH-4km3A:
undetectable
4qvwN-4km3A:
undetectable		 4qvwH-4km3A:
21.85
4qvwN-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.45A 4qvyV-4km3A:
undetectable
4qvyb-4km3A:
0.1		 4qvyV-4km3A:
21.85
4qvyb-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.42A 4qw0V-4km3A:
undetectable
4qw0b-4km3A:
undetectable		 4qw0V-4km3A:
21.85
4qw0b-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.42A 4qw0H-4km3A:
undetectable
4qw0N-4km3A:
undetectable		 4qw0H-4km3A:
21.85
4qw0N-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.42A 4qw3V-4km3A:
undetectable
4qw3b-4km3A:
undetectable		 4qw3V-4km3A:
21.85
4qw3b-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.43A 4qw3H-4km3A:
undetectable
4qw3N-4km3A:
undetectable		 4qw3H-4km3A:
21.85
4qw3N-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 153
LEU A  94
THR A 254
THR A 237
 None
 0.79A 4z90A-4km3A:
undetectable
4z90B-4km3A:
undetectable
4z90C-4km3A:
undetectable
4z90D-4km3A:
undetectable
4z90E-4km3A:
undetectable		 4z90A-4km3A:
20.60
4z90B-4km3A:
20.60
4z90C-4km3A:
20.60
4z90D-4km3A:
20.60
4z90E-4km3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 9 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.48A 5cz7V-4km3A:
undetectable
5cz7b-4km3A:
0.1		 5cz7V-4km3A:
21.85
5cz7b-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.47A 5cz7H-4km3A:
undetectable
5cz7N-4km3A:
undetectable		 5cz7H-4km3A:
21.85
5cz7N-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.43A 5d0xV-4km3A:
undetectable
5d0xb-4km3A:
undetectable		 5d0xV-4km3A:
21.85
5d0xb-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  74
THR A 248
THR A 244
ARG A  85
ALA A  82
 None
 1.42A 5d0xH-4km3A:
undetectable
5d0xN-4km3A:
undetectable		 5d0xH-4km3A:
21.85
5d0xN-4km3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		3 / 3 MET A 161
HIS A 265
GLY A 284
 None
 0.71A 5gwzB-4km3A:
undetectable		 5gwzB-4km3A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A  27
LEU A  30
GLN A 280
TYR A 286
 None
 1.28A 5uc3A-4km3A:
undetectable		 5uc3A-4km3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  95
GLU A  41
VAL A  40
GLU A  78
THR A 248
 None
 1.13A 5xipC-4km3A:
undetectable		 5xipC-4km3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 8 GLN A 262
VAL A  79
ILE A 242
THR A 244
 None
 0.92A 6cduG-4km3A:
undetectable
6cduH-4km3A:
undetectable		 6cduG-4km3A:
20.77
6cduH-4km3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4km3 METHIONINE
AMINOPEPTIDASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A  98
ASP A 136
GLN A 262
TYR A  67
 None
 1.25A 6g31G-4km3A:
undetectable		 6g31G-4km3A:
14.75