SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 6 VAL A 265
GLY A 264
LEU A 262
GLU A 205
 None
 1.00A 1fduD-4kmaA:
undetectable		 1fduD-4kmaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 7 GLY A  84
HIS A  83
THR A 186
THR A 188
 None
 0.92A 1gtnF-4kmaA:
undetectable
1gtnG-4kmaA:
undetectable		 1gtnF-4kmaA:
8.63
1gtnG-4kmaA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 7 GLY A  84
HIS A  83
THR A 186
THR A 188
 None
 0.96A 1gtnJ-4kmaA:
undetectable
1gtnK-4kmaA:
undetectable		 1gtnJ-4kmaA:
8.63
1gtnK-4kmaA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4kma GM14141P
(Drosophila
melanogaster) 		3 / 3 TRP A  45
THR A  39
TYR A  54
 None
 0.98A 2a3aA-4kmaA:
undetectable		 2a3aA-4kmaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4kma GM14141P
(Drosophila
melanogaster) 		3 / 3 TRP A  45
THR A  39
TYR A  54
 None
 1.01A 2a3aB-4kmaA:
undetectable		 2a3aB-4kmaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4kma GM14141P
(Drosophila
melanogaster) 		3 / 3 TRP A  45
THR A  39
TYR A  54
 None
 0.99A 2a3bA-4kmaA:
undetectable		 2a3bA-4kmaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4kma GM14141P
(Drosophila
melanogaster) 		3 / 3 ASP A 228
ASP A 222
ASP A  65
 None
 0.62A 2igtA-4kmaA:
undetectable		 2igtA-4kmaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4kma GM14141P
(Drosophila
melanogaster) 		3 / 3 ASP A 228
ASP A 222
ASP A  65
 None
 0.63A 2igtB-4kmaA:
undetectable		 2igtB-4kmaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 5 GLN A 206
PHE A 241
PHE A 218
GLY A 212
 None
 1.39A 2qmzA-4kmaA:
undetectable
2qmzB-4kmaA:
undetectable		 2qmzA-4kmaA:
17.76
2qmzB-4kmaA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4kma GM14141P
(Drosophila
melanogaster) 		3 / 3 CYH A 143
PRO A 312
ASP A 154
 None
 0.69A 3hlwB-4kmaA:
undetectable		 3hlwB-4kmaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 8 ILE A 450
LEU A 448
PHE A 422
LYS A 363
 None
 1.01A 3selX-4kmaA:
undetectable		 3selX-4kmaA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4kma GM14141P
(Drosophila
melanogaster) 		5 / 9 ILE A 450
LEU A 448
PHE A 422
MET A 419
LYS A 363
 None
 1.29A 3sj4X-4kmaA:
undetectable		 3sj4X-4kmaA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 7 ILE A 450
LEU A 448
ALA A 355
ALA A 425
 None
 0.82A 4g77A-4kmaA:
undetectable		 4g77A-4kmaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 7 ILE A 450
LEU A 448
PHE A 422
LYS A 363
 None
 1.06A 4hc3A-4kmaA:
undetectable		 4hc3A-4kmaA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4kma GM14141P
(Drosophila
melanogaster) 		5 / 10 LEU A 427
ALA A 267
PHE A 374
PHE A 372
LEU A 360
 None
 1.29A 4la0A-4kmaA:
undetectable		 4la0A-4kmaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4kma GM14141P
(Drosophila
melanogaster) 		3 / 3 CYH A 143
PRO A 312
ASP A 154
 None
 0.73A 4pm5A-4kmaA:
undetectable		 4pm5A-4kmaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4kma GM14141P
(Drosophila
melanogaster) 		5 / 10 LEU A 255
LEU A 251
LEU A 174
LEU A 204
VAL A 199
 None
 0.83A 4po0A-4kmaA:
undetectable		 4po0A-4kmaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 5 GLY A 198
ARG A 236
GLU A 203
PHE A 200
 None
 1.33A 4r82A-4kmaA:
undetectable
4r82B-4kmaA:
undetectable		 4r82A-4kmaA:
16.60
4r82B-4kmaA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4kma GM14141P
(Drosophila
melanogaster) 		5 / 9 PHE A 372
VAL A 354
VAL A 265
PHE A 269
LEU A 350
 None
 1.34A 4wnvA-4kmaA:
undetectable		 4wnvA-4kmaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 5 LEU A 115
LYS A 110
HIS A  71
VAL A  68
 None
 1.21A 5jmnB-4kmaA:
undetectable		 5jmnB-4kmaA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4kma GM14141P
(Drosophila
melanogaster) 		5 / 12 ARG A 159
LEU A 204
ASN A 155
ASP A 261
GLY A 264
 None
 1.10A 5kqyA-4kmaA:
undetectable		 5kqyA-4kmaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4kma GM14141P
(Drosophila
melanogaster) 		3 / 3 LYS A 160
GLN A 137
ASN A 134
 None
 0.84A 5l2tA-4kmaA:
undetectable		 5l2tA-4kmaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 5 PRO A 122
GLN A 126
LYS A 110
GLN A 118
 None
 1.43A 5odcA-4kmaA:
undetectable
5odcG-4kmaA:
undetectable		 5odcA-4kmaA:
21.35
5odcG-4kmaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4kma GM14141P
(Drosophila
melanogaster) 		4 / 8 ILE A 450
LEU A 427
ALA A 361
LEU A 383
 None
 0.76A 5y7pE-4kmaA:
undetectable		 5y7pE-4kmaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4kma GM14141P
(Drosophila
melanogaster) 		5 / 12 ASP A 154
THR A 105
PRO A  51
GLY A  78
LEU A  52
 None
 1.18A 6b0lB-4kmaA:
undetectable		 6b0lB-4kmaA:
9.09