SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		4 / 7 ASP A 237
GLU A 207
GLU A 246
GLU A 206
 None
 1.18A 1knyA-4kmhA:
undetectable
1knyB-4kmhA:
undetectable		 1knyA-4kmhA:
18.63
1knyB-4kmhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		5 / 11 SER A 114
ASP A 101
ASN A 102
THR A 108
GLY A 109
 None
 1.45A 2hmaA-4kmhA:
0.2		 2hmaA-4kmhA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		4 / 4 LEU A 234
GLN A 217
THR A 180
THR A 225
 None
 1.46A 2zj0D-4kmhA:
undetectable		 2zj0D-4kmhA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 263
GLY A 387
SER A 210
ILE A 219
GLY A 258
 None
 0.99A 3axzA-4kmhA:
undetectable		 3axzA-4kmhA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		4 / 7 PRO A  67
GLY A 143
GLU A 139
ALA A 145
 None
 0.98A 3tehB-4kmhA:
undetectable		 3tehB-4kmhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		5 / 12 SER A 377
GLN A 432
ILE A 406
PHE A 408
HIS A 394
 None
 1.29A 4c49D-4kmhA:
undetectable		 4c49D-4kmhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		5 / 9 LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
 None
 1.42A 4c9kB-4kmhA:
undetectable		 4c9kB-4kmhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 230
GLY A 231
LEU A 179
ASP A 159
GLY A 158
 None
 1.03A 4fp9D-4kmhA:
undetectable		 4fp9D-4kmhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 263
GLY A 387
SER A 210
ILE A 219
GLY A 258
 None
 0.99A 4yvgA-4kmhA:
undetectable		 4yvgA-4kmhA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		4 / 5 PHE A 116
PHE A 155
PHE A 118
VAL A 148
 None
 1.21A 5a1rA-4kmhA:
undetectable		 5a1rA-4kmhA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE A 373
ALA A 274
HIS A 370
LEU A 474
 None
 1.18A 5dzkg-4kmhA:
undetectable
5dzku-4kmhA:
undetectable		 5dzkg-4kmhA:
18.80
5dzku-4kmhA:
1.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		4 / 8 LEU A 223
ILE A 219
ALA A 211
PRO A 183
 None
 0.99A 5m0oC-4kmhA:
undetectable		 5m0oC-4kmhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 4kmh SUPPRESSOR OF FUSED
HOMOLOG
(Homo
sapiens) 		3 / 3 GLU A 207
HIS A 176
VAL A 203
 None
 0.84A 5trqB-4kmhA:
undetectable		 5trqB-4kmhA:
19.33