SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4kml MAJOR PRION PROTEIN
(Homo
sapiens) 		3 / 3 GLN A 186
ILE A 182
TYR A 162
 None
 0.73A 1vifA-4kmlA:
undetectable		 1vifA-4kmlA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4kml NANOBODY
(Lama
glama) 		5 / 12 ALA B  23
GLY B 117
THR B  93
GLU B   6
LEU B   4
 None
 1.21A 2zifA-4kmlB:
undetectable		 2zifA-4kmlB:
16.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4kml NANOBODY
(Lama
glama) 		5 / 12 VAL B   2
ALA B  24
MET B  34
ARG B  72
ASN B  77
 None
 0.91A 3qxtA-4kmlB:
23.0		 3qxtA-4kmlB:
67.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4kml NANOBODY
(Lama
glama) 		3 / 3 TYR B  80
MET B  79
ILE B 104
 None
 0.88A 4c8bB-4kmlB:
undetectable		 4c8bB-4kmlB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4kml NANOBODY
(Lama
glama) 		3 / 3 ARG B  98
HIS B 113
TYR B  32
 None
 1.01A 4fu8A-4kmlB:
undetectable		 4fu8A-4kmlB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4kml NANOBODY
(Lama
glama) 		3 / 3 ARG B  98
HIS B 113
TYR B  32
 None
 1.05A 4fu9A-4kmlB:
undetectable		 4fu9A-4kmlB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4kml NANOBODY
(Lama
glama) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.88A 5jsdA-4kmlB:
undetectable		 5jsdA-4kmlB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4kml NANOBODY
(Lama
glama) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.87A 5jseB-4kmlB:
undetectable		 5jseB-4kmlB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4kml NANOBODY
(Lama
glama) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.88A 5jseC-4kmlB:
2.6		 5jseC-4kmlB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4kml MAJOR PRION PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 157
ASP A 202
THR A 199
TYR A 149
 None
 1.11A 5ov9A-4kmlA:
undetectable		 5ov9A-4kmlA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4kml NANOBODY
(Lama
glama) 		3 / 3 TYR B  60
GLY B  66
THR B  69
 None
 0.15A 6cjkB-4kmlB:
19.3		 6cjkB-4kmlB:
31.90