SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ARG B 534
GLY B 533
LEU B 560
VAL B 564
LEU B 540
 None
 1.08A 1gseB-4kmoB:
2.0		 1gseB-4kmoB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 ARG B 596
ALA B 623
SER B 624
TYR B 613
 None
 1.44A 1j36A-4kmoB:
0.9		 1j36A-4kmoB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 ARG B 596
ALA B 623
SER B 624
TYR B 613
 None
 1.45A 1j36B-4kmoB:
0.9		 1j36B-4kmoB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 GLN B 756
PHE B 753
PHE B 769
LEU B 765
 None
 0.96A 3ablP-4kmoB:
undetectable
3ablW-4kmoB:
undetectable		 3ablP-4kmoB:
19.53
3ablW-4kmoB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG B 579
ARG B 584
ASP B 545
 None
 0.85A 3wipG-4kmoB:
undetectable
3wipH-4kmoB:
undetectable		 3wipG-4kmoB:
20.65
3wipH-4kmoB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ARG B 724
VAL B 757
PHE B 753
GLU B 738
 None
 1.01A 4jseA-4kmoB:
undetectable
4jseB-4kmoB:
2.2		 4jseA-4kmoB:
23.06
4jseB-4kmoB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE B 753
GLU B 738
ARG B 724
VAL B 757
 None
 1.02A 4jseA-4kmoB:
undetectable
4jseB-4kmoB:
2.2		 4jseA-4kmoB:
23.06
4jseB-4kmoB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP B 559
LEU B 560
PHE B 563
 None
 0.36A 4pthA-4kmoB:
undetectable		 4pthA-4kmoB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG B 618
ASP B 617
ARG B 619
 None
 0.63A 4wq4B-4kmoB:
undetectable		 4wq4B-4kmoB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 GLN B 756
PHE B 753
PHE B 769
LEU B 765
 None
 0.94A 5b1bC-4kmoB:
undetectable
5b1bJ-4kmoB:
undetectable		 5b1bC-4kmoB:
19.53
5b1bJ-4kmoB:
11.55