SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kmr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		3 / 3 VAL A 227
VAL A 225
TRP A 230
 None
 0.84A 1bdwA-4kmrA:
undetectable
1bdwB-4kmrA:
undetectable		 1bdwA-4kmrA:
6.19
1bdwB-4kmrA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 PHE A 253
LEU A 203
ALA A 172
ALA A 175
LEU A 296
 None
 1.20A 1cbrA-4kmrA:
undetectable		 1cbrA-4kmrA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 PHE A 253
LEU A 203
ALA A 172
ALA A 175
LEU A 296
 None
 1.20A 1cbrB-4kmrA:
undetectable		 1cbrB-4kmrA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		4 / 7 ASP A 221
ASP A 220
TYR A 205
ARG A 209
 None
 1.47A 1cebA-4kmrA:
undetectable		 1cebA-4kmrA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.98A 1eqhA-4kmrA:
undetectable		 1eqhA-4kmrA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.98A 1eqhB-4kmrA:
1.2		 1eqhB-4kmrA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		4 / 5 TYR A 208
ARG A 209
THR A 213
LEU A 217
 None
 1.28A 2eimJ-4kmrA:
undetectable		 2eimJ-4kmrA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		4 / 5 TYR A 208
ARG A 209
THR A 213
LEU A 217
 None
 1.21A 3ag2J-4kmrA:
undetectable		 3ag2J-4kmrA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		4 / 5 TYR A 208
ARG A 209
THR A 213
LEU A 217
 None
 1.36A 3ag4J-4kmrA:
undetectable		 3ag4J-4kmrA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 GLY A 289
SER A 342
THR A 343
LEU A 261
ALA A 260
 None
 0.91A 3d91A-4kmrA:
undetectable		 3d91A-4kmrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 1.02A 3n8zA-4kmrA:
undetectable		 3n8zA-4kmrA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 LEU A 189
GLU A 237
GLY A 191
LEU A 259
ALA A 240
 None
 1.20A 3ou6C-4kmrA:
2.1		 3ou6C-4kmrA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.89A 3pghC-4kmrA:
undetectable		 3pghC-4kmrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.99A 3rr3A-4kmrA:
undetectable		 3rr3A-4kmrA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.99A 3rr3B-4kmrA:
undetectable		 3rr3B-4kmrA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 GLY A 302
LEU A 129
GLN A  97
VAL A  93
ALA A  94
 None
 1.24A 3t7vA-4kmrA:
undetectable		 3t7vA-4kmrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		3 / 3 ARG A 110
LEU A 114
GLU A 113
 None
 0.63A 4l3gF-4kmrA:
undetectable		 4l3gF-4kmrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		4 / 4 THR A 298
ARG A 336
GLU A 300
VAL A 338
 None
 1.04A 4odoC-4kmrA:
undetectable		 4odoC-4kmrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 10 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.93A 4ph9A-4kmrA:
undetectable		 4ph9A-4kmrA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 10 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.94A 4ph9B-4kmrA:
undetectable		 4ph9B-4kmrA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		3 / 3 GLY A 108
GLY A 107
GLN A  80
 None
 0.39A 5imsA-4kmrA:
5.5		 5imsA-4kmrA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 GLU A 104
LEU A 135
LEU A 130
LEU A 149
GLU A 115
 None
 1.12A 5v0vA-4kmrA:
undetectable		 5v0vA-4kmrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 ALA A 131
GLY A 153
GLU A 154
LEU A 156
ASP A 162
 None
 1.34A 5vlmF-4kmrA:
undetectable		 5vlmF-4kmrA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		4 / 4 TYR A 208
ARG A 209
THR A 213
LEU A 217
 None
 1.19A 5wauj-4kmrA:
0.0		 5wauj-4kmrA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		4 / 5 TYR A 208
ARG A 209
THR A 213
LEU A 217
 None
 1.23A 5z86J-4kmrA:
undetectable		 5z86J-4kmrA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Sanguibacter
keddieii) 		5 / 12 LEU A 149
LEU A 129
THR A 125
ILE A  71
VAL A  70
 None
 1.16A 6debB-4kmrA:
5.5		 6debB-4kmrA:
11.85