SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4kms ACETOACETYL-COA
REDUCTASE
(Rickettsia
felis) 		4 / 8 ILE A 234
SER A 233
ARG A 205
GLU A 211
 None
 0.97A 2cdqA-4kmsA:
1.6		 2cdqA-4kmsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4kms ACETOACETYL-COA
REDUCTASE
(Rickettsia
felis) 		4 / 7 THR A 166
ILE A 130
ASN A 132
PHE A 158
 None
 1.26A 2jc9A-4kmsA:
4.4		 2jc9A-4kmsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4kms ACETOACETYL-COA
REDUCTASE
(Rickettsia
felis) 		5 / 9 PHE A 218
ALA A 215
ALA A 213
LEU A 219
VAL A 220
 None
 1.21A 4or0A-4kmsA:
undetectable		 4or0A-4kmsA:
16.67