SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kmz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
4 / 5 SER A 188
ARG A 119
LEU A 124
SER A 190
None
FOL  A 301 (-3.0A)
None
FOL  A 301 (-2.6A)
1.24A 2qhfA-4kmzA:
undetectable
2qhfA-4kmzA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
3 / 3 SER A 190
TYR A 191
HIS A 189
FOL  A 301 (-2.6A)
FOL  A 301 (-4.1A)
None
0.64A 2r2vD-4kmzA:
undetectable
2r2vD-4kmzA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
4 / 7 THR A 145
TRP A 154
ASN A  79
PHE A 172
None
1.28A 4awuA-4kmzA:
undetectable
4awuA-4kmzA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JI8_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
3 / 3 LYS A  91
LYS A  85
TRP A  80
None
1.26A 4ji8L-4kmzA:
0.0
4ji8L-4kmzA:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMZ_A_FOLA301_0
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
12 / 12 TYR A  76
TYR A 101
GLN A 116
SER A 117
TRP A 118
ARG A 122
PHE A 123
HIS A 151
ARG A 152
TRP A 154
TRP A 187
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
None
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
0.00A 4kmzA-4kmzA:
40.1
4kmzA-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMZ_A_FOLA301_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
4 / 4 ASP A  97
ARG A 119
TRP A 156
SER A 190
FOL  A 301 (-2.8A)
FOL  A 301 (-3.0A)
FOL  A 301 (-3.7A)
FOL  A 301 (-2.6A)
0.03A 4kmzA-4kmzA:
40.1
4kmzA-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN0_A_MTXA301_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
10 / 12 TYR A  76
PHE A  78
ASP A  97
TYR A 101
GLN A 116
ARG A 152
GLY A 153
TRP A 156
TRP A 187
SER A 190
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.9A)
FOL  A 301 (-2.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-2.6A)
0.82A 4kn0A-4kmzA:
36.9
4kn0A-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN0_A_MTXA301_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
11 / 12 TYR A  76
PHE A  78
ASP A  97
TYR A 101
GLN A 116
TRP A 118
ARG A 119
ARG A 152
GLY A 153
TRP A 156
TRP A 187
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.9A)
FOL  A 301 (-2.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 (-4.0A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
0.69A 4kn0A-4kmzA:
36.9
4kn0A-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
5 / 12 ASP A  97
ARG A 122
HIS A 151
GLY A 153
TRP A 187
FOL  A 301 (-2.8A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.5A)
1.09A 4kn2A-4kmzA:
37.6
4kn2A-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
12 / 12 ASP A  97
THR A  98
TYR A 101
SER A 117
TRP A 118
ARG A 119
HIS A 151
GLY A 153
TRP A 156
TRP A 187
SER A 190
TYR A 191
FOL  A 301 (-2.8A)
FOL  A 301 ( 4.6A)
FOL  A 301 (-3.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-2.6A)
FOL  A 301 (-4.1A)
0.32A 4kn2A-4kmzA:
37.6
4kn2A-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN2_A_LYAA304_2
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
4 / 4 TYR A  76
GLN A 116
ARG A 152
TRP A 154
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-4.0A)
None
0.16A 4kn2A-4kmzA:
37.6
4kn2A-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN2_B_LYAB304_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
6 / 12 ASP A  97
ARG A 122
HIS A 151
ARG A 152
GLY A 153
TRP A 187
FOL  A 301 (-2.8A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.5A)
1.42A 4kn2B-4kmzA:
37.5
4kn2B-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN2_B_LYAB304_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
12 / 12 ASP A  97
THR A  98
TYR A 101
TRP A 118
ARG A 119
HIS A 151
ARG A 152
GLY A 153
TRP A 156
TRP A 187
SER A 190
TYR A 191
FOL  A 301 (-2.8A)
FOL  A 301 ( 4.6A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-2.6A)
FOL  A 301 (-4.1A)
0.29A 4kn2B-4kmzA:
37.5
4kn2B-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
5 / 12 ASP A  97
ARG A 122
HIS A 151
GLY A 153
TRP A 187
FOL  A 301 (-2.8A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.5A)
1.08A 4kn2C-4kmzA:
37.4
4kn2C-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
12 / 12 ASP A  97
THR A  98
TYR A 101
SER A 117
TRP A 118
ARG A 119
HIS A 151
GLY A 153
TRP A 156
TRP A 187
SER A 190
TYR A 191
FOL  A 301 (-2.8A)
FOL  A 301 ( 4.6A)
FOL  A 301 (-3.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-2.6A)
FOL  A 301 (-4.1A)
0.28A 4kn2C-4kmzA:
37.4
4kn2C-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
3 / 3 TYR A  76
GLN A 116
TRP A 154
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
None
0.20A 4kn2C-4kmzA:
37.4
4kn2C-4kmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_A_FOLA301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
11 / 12 TYR A  76
TYR A 101
GLN A 116
SER A 117
TRP A 118
ARG A 119
ARG A 122
HIS A 151
TRP A 154
TRP A 187
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
0.47A 4lrhA-4kmzA:
35.2
4lrhA-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_A_FOLA301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
5 / 12 TYR A 101
ARG A 119
ARG A 122
HIS A 151
TRP A 150
FOL  A 301 (-3.8A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
1.45A 4lrhA-4kmzA:
35.2
4lrhA-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
3 / 3 ASP A  97
TRP A 156
SER A 190
FOL  A 301 (-2.8A)
FOL  A 301 (-3.7A)
FOL  A 301 (-2.6A)
0.25A 4lrhA-4kmzA:
35.2
4lrhA-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_B_FOLB301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
11 / 12 TYR A  76
TYR A 101
GLN A 116
SER A 117
ARG A 119
ARG A 122
HIS A 151
TRP A 154
TRP A 156
TRP A 187
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
0.66A 4lrhB-4kmzA:
35.3
4lrhB-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_B_FOLB301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
5 / 12 TYR A 101
ARG A 119
ARG A 122
HIS A 151
TRP A 150
FOL  A 301 (-3.8A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
1.28A 4lrhB-4kmzA:
35.3
4lrhB-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
3 / 3 ASP A  97
TRP A 118
SER A 190
FOL  A 301 (-2.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-2.6A)
0.57A 4lrhB-4kmzA:
35.3
4lrhB-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_C_FOLC301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
12 / 12 TYR A  76
ASP A  97
TYR A 101
GLN A 116
TRP A 118
ARG A 119
ARG A 122
HIS A 151
TRP A 154
TRP A 156
TRP A 187
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-2.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
0.49A 4lrhC-4kmzA:
34.7
4lrhC-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_D_FOLD301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
11 / 12 TYR A  76
ASP A  97
TYR A 101
GLN A 116
SER A 117
TRP A 118
ARG A 119
ARG A 122
TRP A 154
TRP A 187
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-2.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
None
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
0.49A 4lrhD-4kmzA:
34.8
4lrhD-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
3 / 3 HIS A 151
TRP A 156
SER A 190
FOL  A 301 (-3.9A)
FOL  A 301 (-3.7A)
FOL  A 301 (-2.6A)
0.24A 4lrhD-4kmzA:
34.8
4lrhD-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_E_FOLE301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
11 / 12 TYR A  76
ASP A  97
TYR A 101
GLN A 116
TRP A 118
ARG A 119
ARG A 122
HIS A 151
TRP A 156
TRP A 187
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-2.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
0.49A 4lrhE-4kmzA:
35.0
4lrhE-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_F_FOLF301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
11 / 12 TYR A  76
TYR A 101
GLN A 116
ARG A 119
ARG A 122
HIS A 151
GLY A 153
TRP A 154
TRP A 156
TRP A 187
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
FOL  A 301 (-4.0A)
None
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
0.49A 4lrhF-4kmzA:
34.8
4lrhF-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_F_FOLF301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
5 / 12 TYR A 101
ARG A 119
ARG A 122
HIS A 151
TRP A 150
FOL  A 301 (-3.8A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
1.46A 4lrhF-4kmzA:
34.8
4lrhF-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
3 / 3 ASP A  97
TRP A 118
SER A 190
FOL  A 301 (-2.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-2.6A)
0.61A 4lrhF-4kmzA:
34.8
4lrhF-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_G_FOLG301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
11 / 12 TYR A  76
TYR A 101
GLN A 116
TRP A 118
ARG A 119
ARG A 122
GLY A 153
TRP A 156
TRP A 187
SER A 190
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-2.6A)
FOL  A 301 (-4.1A)
0.56A 4lrhG-4kmzA:
35.0
4lrhG-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_H_FOLH301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
11 / 12 TYR A  76
TYR A 101
GLN A 116
TRP A 118
ARG A 119
ARG A 122
HIS A 151
TRP A 154
TRP A 156
TRP A 187
TYR A 191
FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
0.47A 4lrhH-4kmzA:
35.7
4lrhH-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LRH_H_FOLH301_0
(FOLATE RECEPTOR
ALPHA)
4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)
5 / 12 TYR A 101
ARG A 119
ARG A 122
HIS A 151
TRP A 150
FOL  A 301 (-3.8A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
1.38A 4lrhH-4kmzA:
35.7
4lrhH-4kmzA:
77.36