SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kna'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ALA A 180
VAL A 182
TRP A 185
 None
 0.91A 1av2A-4knaA:
undetectable
1av2B-4knaA:
undetectable		 1av2A-4knaA:
2.72
1av2B-4knaA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A  42
THR A   2
VAL A  11
 None
 0.89A 1hxbA-4knaA:
undetectable		 1hxbA-4knaA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ALA A 180
VAL A 182
TRP A 185
 None
 0.91A 1w5uA-4knaA:
undetectable
1w5uB-4knaA:
undetectable		 1w5uA-4knaA:
2.72
1w5uB-4knaA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 364
LEU A 338
VAL A 369
LEU A 372
ARG A 283
 None
 1.21A 2bxfA-4knaA:
undetectable		 2bxfA-4knaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 PHE A 443
ALA A 437
SER A 438
ALA A 440
GLY A 436
 None
 1.26A 2igtC-4knaA:
3.4		 2igtC-4knaA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 TRP A 185
ALA A 180
VAL A 182
 None
 0.93A 2izqC-4knaA:
undetectable
2izqD-4knaA:
undetectable		 2izqC-4knaA:
2.72
2izqD-4knaA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A  42
THR A   2
VAL A  11
 None
 0.82A 2q64A-4knaA:
undetectable		 2q64A-4knaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A  42
THR A   2
VAL A  11
 None
 0.84A 2qakA-4knaA:
undetectable		 2qakA-4knaA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 GLY A 154
ASN A 153
ALA A 159
VAL A 166
 None
 0.74A 3a2qA-4knaA:
undetectable		 3a2qA-4knaA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 VAL A 139
VAL A 138
PHE A 168
ARG A 212
 None
 1.37A 3bjwH-4knaA:
undetectable		 3bjwH-4knaA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 334
ALA A 327
VAL A 322
GLY A 275
VAL A 366
 EDO  A 503 ( 4.0A)
None
None
None
None
 1.07A 3c6gB-4knaA:
undetectable		 3c6gB-4knaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 LYS A 169
ARG A  42
GLN A 199
GLU A 172
 None
 1.25A 3dh0A-4knaA:
3.1		 3dh0A-4knaA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 TRP A 185
ALA A 180
VAL A 182
 None
 0.93A 3l8lC-4knaA:
undetectable
3l8lD-4knaA:
undetectable		 3l8lC-4knaA:
2.72
3l8lD-4knaA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 ILE A  65
PHE A  69
ALA A 159
LEU A 160
ALA A 188
 None
 1.01A 3ozvB-4knaA:
2.4		 3ozvB-4knaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 ALA A 192
PRO A 191
ARG A  62
ALA A  53
 None
 1.09A 3twpB-4knaA:
2.9		 3twpB-4knaA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 277
GLU A  98
THR A  97
 None
 0.88A 3v4tA-4knaA:
0.0		 3v4tA-4knaA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 PHE A 295
ASP A 293
ARG A 386
 None
 0.77A 4eahF-4knaA:
undetectable		 4eahF-4knaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 PHE A 295
ASP A 293
ARG A 386
 None
 0.77A 4eahG-4knaA:
undetectable		 4eahG-4knaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 PRO A  91
GLY A  24
ALA A 313
GLN A 351
 None
 1.06A 4g0uA-4knaA:
undetectable		 4g0uA-4knaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 MET A 102
LEU A  73
PRO A 158
SER A 109
 None
 1.35A 4kmmB-4knaA:
undetectable		 4kmmB-4knaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 426
ALA A 437
PHE A 443
ASN A 249
GLY A 247
 None
 1.21A 4n09A-4knaA:
3.5		 4n09A-4knaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 THR A  88
THR A  97
LEU A 272
 None
 0.55A 5m66D-4knaA:
4.5		 5m66D-4knaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 SER A  46
ILE A   6
PHE A   5
ALA A   9
GLY A 189
 None
 1.06A 5veuA-4knaA:
undetectable		 5veuA-4knaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 ILE A 423
LEU A 390
HIS A 417
ALA A 415
 None
 0.97A 6ck2C-4knaA:
undetectable
6ck2D-4knaA:
undetectable		 6ck2C-4knaA:
3.18
6ck2D-4knaA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 ILE A 423
ALA A 406
GLY A 407
LEU A 251
GLY A 247
 None
 1.30A 6nm4B-4knaA:
undetectable		 6nm4B-4knaA:
17.92