SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4knc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 12 VAL B 353
ARG B 377
ILE B 399
LEU B 427
ILE B 459
 None
 1.16A 1d1gB-4kncB:
undetectable		 1d1gB-4kncB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 9 THR B 243
GLY B 279
PHE B 207
SER B 285
GLU B 282
 None
 1.25A 1jhoA-4kncB:
undetectable		 1jhoA-4kncB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 9 THR B 243
GLY B 279
PHE B 207
SER B 285
GLU B 282
 None
 1.27A 1jhrA-4kncB:
undetectable		 1jhrA-4kncB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 9 THR B 243
GLY B 279
PHE B 207
SER B 285
GLU B 282
 None
 1.26A 1jhyA-4kncB:
undetectable		 1jhyA-4kncB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 10 GLY B 173
LEU B  43
GLN B  66
THR B 220
GLY B 219
 None
 1.34A 1kvlA-4kncB:
undetectable		 1kvlA-4kncB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 9 THR B 243
GLY B 279
PHE B 207
SER B 285
GLU B 282
 None
 1.31A 1l4nA-4kncB:
undetectable		 1l4nA-4kncB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 9 THR B 243
GLY B 279
PHE B 207
SER B 285
GLU B 282
 None
 1.28A 1l5kA-4kncB:
undetectable		 1l5kA-4kncB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 9 THR B 243
GLY B 279
PHE B 207
SER B 285
GLU B 282
 None
 1.28A 1l5lA-4kncB:
undetectable		 1l5lA-4kncB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 9 THR B 243
GLY B 279
PHE B 207
SER B 285
GLU B 282
 None
 1.29A 1l5mA-4kncB:
undetectable		 1l5mA-4kncB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 12 ILE B 399
PHE B 425
ILE B 459
PHE B 438
VAL B 367
 None
 1.03A 1qhsA-4kncB:
undetectable		 1qhsA-4kncB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		4 / 8 LEU B 107
THR B 192
LEU B 320
VAL B 189
 None
 0.85A 1sn5C-4kncB:
undetectable		 1sn5C-4kncB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		4 / 7 LEU B 107
THR B 192
LEU B 320
VAL B 189
 None
 0.95A 1tyrB-4kncB:
undetectable		 1tyrB-4kncB:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 12 LEU B 427
ASN B 397
PRO B 341
VAL B 424
ILE B 411
 None
 1.48A 2xpwA-4kncB:
undetectable		 2xpwA-4kncB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 12 LEU B 427
ASN B 397
PRO B 341
VAL B 424
ILE B 411
 None
 1.43A 4b3aA-4kncB:
undetectable		 4b3aA-4kncB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		4 / 7 PHE B 324
PHE B 147
GLY B  84
THR B 143
 None
 0.96A 4ejjB-4kncB:
undetectable		 4ejjB-4kncB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		4 / 5 PHE B 324
PHE B 147
GLY B  84
THR B 143
 None
 0.89A 4ejjC-4kncB:
undetectable		 4ejjC-4kncB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		4 / 8 LEU B 107
THR B 192
LEU B 320
VAL B 189
 None
 0.86A 4ik7B-4kncB:
undetectable		 4ik7B-4kncB:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		5 / 9 THR B 243
GLY B 279
PHE B 207
SER B 285
GLU B 282
 None
 1.32A 4kqiA-4kncB:
undetectable		 4kqiA-4kncB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		4 / 4 ASN B 291
SER B 295
ALA B 293
VAL B 266
 None
 1.14A 4x1kC-4kncB:
undetectable		 4x1kC-4kncB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		4 / 4 ASN B 291
SER B 269
ALA B 293
VAL B 266
 None
 1.37A 5nm5A-4kncB:
undetectable		 5nm5A-4kncB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX
(Pseudomonas
aeruginosa) 		3 / 3 GLN B 195
TRP B 153
VAL B 108
 None
 0.74A 6auuA-4kncB:
undetectable		 6auuA-4kncB:
19.92