SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 5 LEU A 445
LEU A 448
SER A 435
LEU A 456
 None
 0.97A 1a4lC-4kngA:
undetectable		 1a4lC-4kngA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 343
LEU A 359
THR A 393
PHE A 394
LEU A 403
 None
 1.09A 1bzfA-4kngA:
undetectable		 1bzfA-4kngA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 LEU A 405
LEU A 434
LEU A 400
LEU A 376
 None
 0.92A 1errA-4kngA:
undetectable		 1errA-4kngA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 5 ILE A 198
LEU A 174
VAL A 153
CYH A 157
 None
 0.79A 1mz9C-4kngA:
undetectable		 1mz9C-4kngA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4kng E3 UBIQUITIN-PROTEIN
LIGASE RNF43
(Homo
sapiens) 		4 / 6 GLU E 131
ALA E 134
LEU E  99
VAL E 137
 None
 0.89A 1sn5A-4kngE:
undetectable		 1sn5A-4kngE:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4kng E3 UBIQUITIN-PROTEIN
LIGASE RNF43
(Homo
sapiens) 		4 / 8 GLU E 131
ALA E 134
LEU E  99
VAL E 137
 None
 0.86A 1sn5C-4kngE:
undetectable		 1sn5C-4kngE:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 ILE A 379
LEU A 333
ILE A 340
LEU A 343
PRO A 344
 None
 0.95A 2d0kA-4kngA:
undetectable		 2d0kA-4kngA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 314
ALA A 315
ILE A 272
PRO A 322
ILE A 318
 None
 0.92A 2hs1A-4kngA:
undetectable		 2hs1A-4kngA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 THR A 334
ASP A 380
ASN A 404
ASP A 428
 None
 1.33A 2okcA-4kngA:
undetectable		 2okcA-4kngA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4kng E3 UBIQUITIN-PROTEIN
LIGASE RNF43
(Homo
sapiens) 		3 / 3 SER E  85
TYR E  89
HIS E  86
 None
 0.77A 2r2vD-4kngE:
undetectable		 2r2vD-4kngE:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 ARG A 144
LEU A 185
LEU A 164
PHE A 158
ALA A 190
 None
 1.19A 2v0mC-4kngA:
undetectable		 2v0mC-4kngA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4kng E3 UBIQUITIN-PROTEIN
LIGASE RNF43
(Homo
sapiens) 		3 / 3 ARG E 113
ARG E 114
PRO E 112
 None
 0.89A 2wljA-4kngE:
undetectable		 2wljA-4kngE:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 SER A  74
GLU A  94
SER A  69
ASP A  51
 None
 1.35A 2zvjA-4kngA:
undetectable		 2zvjA-4kngA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 4 LEU A 193
ARG A 183
LEU A 209
ALA A 205
 None
 1.19A 3b9mA-4kngA:
undetectable		 3b9mA-4kngA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 236
LEU A 262
THR A 255
ILE A 253
ALA A 252
 None
 0.89A 3mdvB-4kngA:
undetectable		 3mdvB-4kngA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 314
ALA A 315
ILE A 272
PRO A 322
ILE A 318
 None
 0.94A 3nu5B-4kngA:
undetectable		 3nu5B-4kngA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		3 / 3 GLN A 141
GLU A  93
LYS A 117
 None
 1.01A 3su9A-4kngA:
undetectable		 3su9A-4kngA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 ILE A 340
ILE A 318
ALA A 338
LEU A 333
LEU A 310
 None
 0.98A 3uvvA-4kngA:
undetectable		 3uvvA-4kngA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 LEU A 256
ASN A 280
LEU A 241
ILE A 286
 None
 0.92A 4okxA-4kngA:
undetectable		 4okxA-4kngA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4kng E3 UBIQUITIN-PROTEIN
LIGASE RNF43
(Homo
sapiens) 		5 / 11 LEU E 122
LEU E 151
ALA E 147
LEU E 109
VAL E 137
 None
 1.16A 4p65C-4kngE:
undetectable
4p65D-4kngE:
undetectable
4p65J-4kngE:
undetectable
4p65L-4kngE:
undetectable		 4p65C-4kngE:
10.14
4p65D-4kngE:
11.25
4p65J-4kngE:
11.25
4p65L-4kngE:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 8 PHE A 230
ILE A 253
GLY A 263
ILE A 286
 None
 0.98A 4qogA-4kngA:
undetectable
4qogB-4kngA:
undetectable		 4qogA-4kngA:
17.60
4qogB-4kngA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 PHE A 370
ILE A 386
LEU A 364
LEU A 333
LEU A 357
 None
 1.39A 4qynB-4kngA:
undetectable		 4qynB-4kngA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 PHE A 370
ILE A 386
LEU A 364
LEU A 351
LEU A 357
 None
 1.17A 4qynB-4kngA:
undetectable		 4qynB-4kngA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 4 SER A  74
GLU A  94
SER A  69
ASP A  51
 None
 1.38A 4xucA-4kngA:
undetectable		 4xucA-4kngA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 343
LEU A 403
ILE A 379
LEU A 376
PRO A 352
 None
 1.10A 5ienA-4kngA:
undetectable		 5ienA-4kngA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		4 / 6 ASP A 240
HIS A 218
ILE A 222
TYR A 289
 None
 1.17A 5ih0A-4kngA:
undetectable		 5ih0A-4kngA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A 143
LEU A 167
ALA A 190
SER A 211
LEU A 209
 None
 1.23A 5mwyA-4kngA:
undetectable		 5mwyA-4kngA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens) 		3 / 3 THR A 440
GLU A 467
ASN A 464
 None
 0.86A 6nj9K-4kngA:
undetectable		 6nj9K-4kngA:
21.21