SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4knh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 9 VAL A 323
GLY A 325
ALA A 327
PHE A 429
ILE A 376
 EDO  A1007 ( 4.8A)
None
None
None
None
 1.15A 1cetA-4knhA:
undetectable		 1cetA-4knhA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 11 LEU A 497
ALA A 520
MET A 515
TYR A 475
LEU A 468
 None
 1.25A 1iiuA-4knhA:
undetectable		 1iiuA-4knhA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 7 LEU A 497
MET A 515
TYR A 475
LEU A 468
 None
 1.00A 1kt3A-4knhA:
undetectable		 1kt3A-4knhA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 11 LEU A 497
ALA A 520
MET A 515
TYR A 475
LEU A 468
 None
 1.22A 1kt6A-4knhA:
undetectable		 1kt6A-4knhA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 7 PHE A 373
ALA A 330
PHE A 364
TRP A 331
 None
 1.11A 1lqtA-4knhA:
undetectable		 1lqtA-4knhA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 7 PHE A 373
ALA A 330
PHE A 364
TRP A 331
 None
 1.10A 1lquA-4knhA:
undetectable		 1lquA-4knhA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 9 GLU A 128
ARG A 124
LEU A   7
GLU A   8
ALA A   9
 None
 1.32A 1mj2A-4knhA:
0.7		 1mj2A-4knhA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 9 GLU A 128
ARG A 124
LEU A   7
GLU A   8
ALA A   9
 None
 1.32A 1mj2C-4knhA:
0.7		 1mj2C-4knhA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 9 GLU A 128
ARG A 124
LEU A   7
GLU A   8
ALA A   9
 None
 1.31A 1mjoA-4knhA:
0.6		 1mjoA-4knhA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 9 GLU A 128
ARG A 124
LEU A   7
GLU A   8
ALA A   9
 None
 1.34A 1mjoB-4knhA:
0.6		 1mjoB-4knhA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 9 GLU A 128
ARG A 124
LEU A   7
GLU A   8
ALA A   9
 None
 1.33A 1mjoC-4knhA:
0.6		 1mjoC-4knhA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 11 PHE A 920
LEU A 840
VAL A 836
PHE A 766
VAL A 845
 None
 1.45A 1q23J-4knhA:
undetectable		 1q23J-4knhA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 10 PHE A 920
LEU A 840
VAL A 836
PHE A 766
VAL A 845
 None
 1.48A 1q23K-4knhA:
undetectable		 1q23K-4knhA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 12 VAL A 793
ASN A 842
ILE A 846
VAL A 912
LEU A 790
 None
 1.08A 1r9oA-4knhA:
undetectable		 1r9oA-4knhA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 4 PHE A 412
ASP A 274
PHE A 276
VAL A 236
 EDO  A1004 ( 4.3A)
EDO  A1004 (-4.0A)
EDO  A1004 (-2.6A)
EDO  A1004 ( 4.3A)
 1.50A 1w0fA-4knhA:
undetectable		 1w0fA-4knhA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 7 PHE A 165
PHE A  42
LEU A  17
SER A 244
 None
 1.07A 1wrlE-4knhA:
undetectable		 1wrlE-4knhA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4knh NUP192P
(Chaetomium
thermophilum) 		3 / 3 PRO A 701
THR A 676
PRO A 678
 None
 0.65A 2d55C-4knhA:
undetectable		 2d55C-4knhA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 6 ASP A 431
THR A 289
GLU A 335
GLU A 295
 SO4  A1001 ( 4.9A)
SO4  A1001 ( 4.5A)
SO4  A1001 (-3.2A)
None
 1.28A 2dttB-4knhA:
undetectable
2dttC-4knhA:
undetectable		 2dttB-4knhA:
8.57
2dttC-4knhA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 7 ILE A 555
LEU A 725
PHE A 649
LEU A 644
 None
 0.93A 3adxA-4knhA:
undetectable		 3adxA-4knhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 7 TRP A 118
VAL A 122
THR A 227
LEU A 228
 None
None
None
EDO  A1006 ( 4.2A)
 1.18A 3arrA-4knhA:
undetectable		 3arrA-4knhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 8 VAL A 931
VAL A 932
GLY A 935
LYS A 936
 None
 0.47A 3bjwA-4knhA:
undetectable		 3bjwA-4knhA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 11 LEU A 497
ALA A 529
ALA A 520
MET A 515
TYR A 475
 None
 1.21A 3bszF-4knhA:
undetectable		 3bszF-4knhA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 10 ILE A 555
PHE A 556
TRP A 552
VAL A 651
LEU A 620
 None
 1.17A 3eqmA-4knhA:
undetectable		 3eqmA-4knhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4knh NUP192P
(Chaetomium
thermophilum) 		3 / 3 ARG A 658
ASP A 521
GLN A 393
 None
 0.89A 3lcvB-4knhA:
undetectable		 3lcvB-4knhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 10 ASP A 390
ARG A 517
GLN A 386
ASP A 521
LYS A 608
 None
 1.48A 3n46F-4knhA:
undetectable		 3n46F-4knhA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 9 ILE A 555
LEU A 609
ARG A 397
LEU A 468
GLU A 514
 None
 1.50A 3nxuB-4knhA:
undetectable		 3nxuB-4knhA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 12 ILE A 555
PHE A 556
TRP A 552
VAL A 651
LEU A 620
 None
 1.17A 3s79A-4knhA:
undetectable		 3s79A-4knhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 12 ILE A 245
LEU A 140
ILE A 139
ALA A 160
ILE A  46
 None
 0.95A 3vrmA-4knhA:
undetectable		 3vrmA-4knhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 9 ALA A 943
GLY A 941
LEU A 945
LEU A 940
ASN A 939
 None
 1.46A 3wdmA-4knhA:
undetectable		 3wdmA-4knhA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 5 VAL A 871
LEU A 874
SER A 872
MET A 794
 None
 1.20A 4e1gA-4knhA:
undetectable		 4e1gA-4knhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		3 / 3 GLU A 161
ARG A 252
HIS A 254
 None
 0.69A 4kf9A-4knhA:
1.1		 4kf9A-4knhA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 7 LEU A 730
VAL A 731
PRO A 733
TYR A 827
 None
 0.98A 4lb2A-4knhA:
undetectable		 4lb2A-4knhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 6 ILE A 873
ILE A 850
SER A 929
LEU A 934
 None
 0.95A 4m51A-4knhA:
undetectable		 4m51A-4knhA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 8 GLU A 146
GLN A 153
ILE A 142
LEU A 152
 None
 0.89A 4mj8A-4knhA:
undetectable		 4mj8A-4knhA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 11 LEU A 840
VAL A 894
LEU A 797
LEU A 886
ALA A 883
 None
 1.16A 4p65B-4knhA:
undetectable
4p65D-4knhA:
undetectable
4p65G-4knhA:
undetectable
4p65H-4knhA:
undetectable		 4p65B-4knhA:
2.95
4p65D-4knhA:
2.95
4p65G-4knhA:
2.02
4p65H-4knhA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 5 GLN A 419
LEU A 418
SER A 415
ASP A 229
 None
None
EDO  A1005 (-3.1A)
None
 1.22A 4qtuD-4knhA:
undetectable		 4qtuD-4knhA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		3 / 3 ASP A 105
GLY A 108
ASP A 109
 None
 0.70A 4xdtA-4knhA:
undetectable		 4xdtA-4knhA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 6 LEU A 886
GLU A 888
HIS A 831
PRO A 896
 None
 1.04A 4xi3C-4knhA:
undetectable		 4xi3C-4knhA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 12 ILE A 555
PHE A 556
TRP A 552
VAL A 651
LEU A 620
 None
 1.16A 5jkvA-4knhA:
undetectable		 5jkvA-4knhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 11 ILE A 555
PHE A 556
TRP A 552
VAL A 651
LEU A 620
 None
 1.21A 5jkwA-4knhA:
undetectable		 5jkwA-4knhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 10 ILE A 555
PHE A 556
TRP A 552
VAL A 651
LEU A 620
 None
 1.18A 5jl7A-4knhA:
undetectable		 5jl7A-4knhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4knh NUP192P
(Chaetomium
thermophilum) 		3 / 3 GLN A 548
THR A 551
ASP A 535
 None
 0.75A 5k9dA-4knhA:
undetectable		 5k9dA-4knhA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4knh NUP192P
(Chaetomium
thermophilum) 		5 / 12 LEU A 633
ASP A 630
ALA A 666
PRO A 746
LEU A 749
 None
 1.27A 5syfB-4knhA:
undetectable		 5syfB-4knhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		3 / 3 MET A 794
GLU A 944
ARG A 875
 None
 0.92A 5tjyA-4knhA:
undetectable		 5tjyA-4knhA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4knh NUP192P
(Chaetomium
thermophilum) 		3 / 3 MET A 794
GLU A 944
ARG A 875
 None
 0.84A 5tjzA-4knhA:
undetectable		 5tjzA-4knhA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4knh NUP192P
(Chaetomium
thermophilum) 		4 / 5 ILE A 873
SER A 872
ALA A 863
LEU A 940
 None
 0.97A 6dwnA-4knhA:
undetectable		 6dwnA-4knhA:
5.95