SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4knk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		4 / 6 ASP A 295
HIS A 392
HIS A 329
ASP A 270
 None
 0.86A 3c0zC-4knkA:
undetectable		 3c0zC-4knkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		3 / 3 ILE A 325
PHE A 334
HIS A 386
 None
 0.65A 3h0aA-4knkA:
undetectable		 3h0aA-4knkA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		3 / 3 GLU A 360
HIS A 386
THR A 369
 None
 0.88A 3hkuA-4knkA:
undetectable		 3hkuA-4knkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		3 / 3 GLY A 316
TRP A 368
VAL A 263
 None
 0.60A 3n62B-4knkA:
undetectable		 3n62B-4knkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		3 / 3 GLY A 316
TRP A 368
VAL A 263
 None
 0.62A 3n65B-4knkA:
undetectable		 3n65B-4knkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		3 / 3 GLY A 316
TRP A 368
VAL A 263
 None
 0.62A 3n66B-4knkA:
undetectable		 3n66B-4knkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		4 / 4 ALA A 345
PRO A 259
LEU A 308
HIS A 291
 None
 1.41A 5eskA-4knkA:
undetectable		 5eskA-4knkA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		3 / 3 TYR A 341
TYR A 252
SER A 309
 None
 0.97A 5iktB-4knkA:
undetectable		 5iktB-4knkA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		4 / 7 LEU A 389
TYR A 388
THR A 267
LEU A 399
 None
 0.74A 5jq7B-4knkA:
undetectable		 5jq7B-4knkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4knk BIFUNCTIONAL
AUTOLYSIN
(Staphylococcus
aureus) 		3 / 3 GLY A 316
TRP A 368
VAL A 263
 None
 0.66A 5vuoB-4knkA:
undetectable		 5vuoB-4knkA:
20.63